Table 1 Characteristics between extubation success and failure in patients with negative fluid balance
Variables | Total (n = 1803) | Extubation success (n = 1602) | Extubation failure (n = 201) | P value |
|---|---|---|---|---|
Age, years (median, [IQR]) | 66 (53, 77) | 66 (53, 77) | 69 (57, 78) | 0.055 |
Sex: male (n (%)) | 988 (55) | 879 (55) | 109 (54) | 0.923 |
Weight, Kg (median, [IQR]) | 80 (67, 95) | 80 (67, 95) | 78 (66, 92) | 0.353 |
Ethnicity, (n (%)) | 0.897 | |||
White | 1310 (73) | 1160 (72) | 150 (75) | |
Asian | 34 (2) | 32 (2) | 2 (1) | |
Black | 146 (8) | 132 (8) | 14 (7) | |
Hispanic/Latino | 54 (3) | 49 (3) | 5 (2) | |
Other | 259 (14) | 229 (14) | 30 (15) | |
ICU types, (n (%)) | 0.422 | |||
CCU | 250 (14) | 230 (14) | 20 (10) | |
CSRU | 330 (18) | 292 (18) | 38 (19) | |
MICU | 693 (38) | 613 (38) | 80 (40) | |
SICU | 265 (15) | 230 (14) | 35 (17) | |
TSICU | 265 (15) | 237 (15) | 28 (14) | |
Comorbidities, n (%) | ||||
Diabetes Mellitus | 494 (27) | 433 (27) | 61 (30) | 0.362 |
Chronic Heart failure | 699 (39) | 619 (39) | 80 (40) | 0.809 |
Hypertension | 920 (51) | 815 (51) | 105 (52) | 0.772 |
COPD | 453 (25) | 387 (24) | 66 (33) | 0.01 |
Liver disease | 165 (9) | 148 (9) | 17 (8) | 0.816 |
Tumor | 141 (8) | 130 (8) | 11 (5) | 0.24 |
Renal insufficiency | 268 (15) | 237 (15) | 31 (15) | 0.896 |
PaCO2 before extubation | < 0.001 | |||
< 35 mmHg | 248 (14) | 224 (14) | 24 (12) | |
35–45 mmHg | 860 (48) | 776 (48) | 84 (42) | |
> 45 mmHg | 480 (27) | 399 (25) | 81 (40) | |
Missing data | 215 (12) | 203 (13) | 12 (6) | |
RSBI, breaths/min/L | 59 (46, 76) | 59 (45, 75) | 64 (50, 81) | 0.005 |
Disease severity score before extubation (median, [IQR]) | ||||
SOFA | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 0.315 |
SAPS II | 42 (33, 51) | 41 (32, 51) | 44 (37, 52) | 0.01 |
Fluid balance (ml/kg/24 hours) | −15 (−27, −8) | −15 (− 27, − 8) | -15 (−24, − 7) | 0.412 |
Total Input (ml/kg/24 hours) | 24 (15, 34) | 24 (15, 34) | 26 (16, 36) | 0.048 |
Total Output (ml/kg/24 hours) | 41 (30, 56) | 41 (30, 56) | 43 (31, 56) | 0.386 |
Diuretics, (n (%)) | 697 (39) | 595 (37) | 102 (51) | < 0.001 |
Blood products transfusion, (n (%)) | 441 (24) | 381 (24) | 60 (30) | 0.072 |
MV duration before extubation, hours | 87 (51, 147) | 85 (50, 145) | 106 (62, 156) | 0.002 |
Hospital LOS, days (median, [IQR]) | 15 (9, 24) | 14 (9, 22) | 23 (16, 33) | < 0.001 |
ICU LOS, days (median, [IQR]) | 8 (4, 13) | 7 (4, 12) | 16 (11, 25) | < 0.001 |
Hospital mortality, n (%) | 213 (12) | 174 (11) | 39 (19) | 0.001 |