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Table 4 Association between depression and SF-36 and State Anxiety Inventory results measured one month after surgery. The “N” represents the number of patients with complete data for that domain. The State-Trait Anxiety Inventory S scale represents anxiety associated with an event while the T scale is anxiety level as a personal characteristic

From: Postoperative but not preoperative depression is associated with cognitive impairment after cardiac surgery: exploratory analysis of data from a randomized trial

Scale

N

No Depression

Depression

Regression Coefficienta

Standard Error

P-Valuee

A. Preoperative Depression

  Physical Functioning (median [interquartile range]

187

45.00 [30.00, 65.00]

30.00 [12.50, 48.75]

-10.13

4.78

0.060b

  Physical Health Limits > 0 (%)

189

51 (25.3)

2 (5.9)

-0.65

0.35

0.093c

  Emotional Health Limits > 0 (%)

189

165 (81.7)

21 (61.8)

-0.21

0.26

0.411d

  Energy/Fatigue (median [interquartile range])

189

50.00 [35.00, 60.00]

25.00 [20.00, 35.00]

-12.59

4.44

0.025b

  Emotional Well Being (median [interquartile range])

189

88.00 [78.00, 96.00]

60.00 [52.00, 70.00]

-9.22

3.56

0.028b

  Social Functioning (median [interquartile range])

187

62.50 [37.50, 84.38]

43.75 [25.00, 50.00]

-9.41

6.39

0.179b

  Pain (median [interquartile range])

188

55.00 [45.00, 77.50]

43.75 [22.50, 55.00]

-7.31

5.63

0.218b

  General Health (median [interquartile range])

185

70.00 [60.00, 80.00]

45.00 [31.25, 55.00]

-14.71

3.76

0.001b

  State Trait Anxiety State Scale (median [interquartile range])

188

27.00 [21.00, 34.00]

42.00 [35.25, 47.50]

5.73

2.24

0.028b

  State Trait Anxiety Trait Scale (median [IQR])

181

25.00 [22.00, 32.00]

41.50 [38.00, 47.00]

5.15

2.11

0.032b

B. Postoperative Depression

  Physical Functioning (median [interquartile range])

189

45.00 [30.00, 65.00]

30.00 [12.50, 48.75]

-19.92

4.34

 < 0.001b

  Physical Health Limits > 0 (%)

190

51 (25.3)

2 (5.9)

-0.5952

0.3476

0.087c

  Emotional Health Limits > 0 (%)

190

165 (81.7)

21 (61.8)

-0.484

0.24

0.049d

  Energy/Fatigue (median [interquartile range])

190

50.00 [35.00, 60.00]

25.00 [20.00, 35.00]

-19.10

3.82

 < 0.001b

  Emotional Well Being (median [interquartile range])

190

88.00 [78.00, 96.00]

60.00 [52.00, 70.00]

-21.65

2.83

 < 0.001b

  Social Functioning (median [interquartile range])

188

62.50 [37.50, 84.38]

43.75 [25.00, 50.00]

-16.27

5.67

0.005b

  Pain (median [interquartile range])

189

55.00 [45.00, 77.50]

43.75 [22.50, 55.00]

-22.65

5.00

 < 0.001b

  General Health (median [interquartile range])

187

70.00 [60.00, 80.00]

45.00 [31.25, 55.00]

-17.90

3.36

 < 0.001b

  State Trait Anxiety State Scale (median [interquartile range])

191

27.00 [21.00, 34.00]

42.00 [35.25, 47.50]

13.74

1.87

 < 0.001b

  State Trait Anxiety Trait Scale (median [interquartile range])

183

25.00 [22.00, 32.00]

41.50 [38.00, 47.00]

12.28

1.71

 < 0.001b

  1. aFor continuous outcomes, estimate is the linear regression coefficient for depression; for dichotomized outcomes, estimate is the log odds coefficient for depression;
  2. bP-value from multivariable linear regression model adjusting for age, sex, education, baseline score, treatment arm, diabetes, obesity, prior stroke, hypertension, atrial fibrillation, and COPD;
  3. cP-value from logistic regression model, with outcome dichotomized at 0, adjusting for baseline score and treatment arm only due to small cell counts;
  4. dP-value from logistic regression model, with outcome dichotomized at 0, adjusting for age, sex, education, baseline score, treatment arm, diabetes, obesity, prior stroke, hypertension, atrial fibrillation, and COPD
  5. eFalse discovery rate correction for multiple testing applied