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Table 3 Associations between postoperative depression and test results for specific cognitive domains one month after surgery adjusted for sex, age, education, baseline cognitive domain z-score, parent study randomized blood pressure management treatment arm, diabetes, obesity, prior stroke, hypertension, atrial fibrillation, and COPD. A negative regression coefficient indicates worse performance for patients with depression compared with those without depression The “N” represents the number of patients with complete data

From: Postoperative but not preoperative depression is associated with cognitive impairment after cardiac surgery: exploratory analysis of data from a randomized trial

Cognitive Domain

N*

No Postoperative Depression

Postoperative Depression

Regression Coefficientb

Standard Error

P-Valuea

Mean (SD)

Mean (SD)

Attention

235

0.67 (1.05)

0.30 (0.85)

-0.44

0.18

0.030

Memory

235

0.41 (0.87)

0.02 (0.99)

-0.25

0.13

0.065

Visuoconstruction

222

0.09 (0.98)

-0.13 (1.35)

-0.02

0.17

0.9897

Verbal Fluency

226

0.14 (1.01)

-0.23 (0.89)

-0.37

0.11

0.011

Processing Speed

225

0.18 (0.91)

-0.41 (1.58)

-0.34

0.15

0.044

Executive Function

203

0.11 (0.99)

-0.04 (0.88)

0.07

0.14

0.751

Fine Motor Speed

200

0.29 (0.60)

-0.21 (1.20)

-0.35

0.13

0.030

  1. aFalse discovery rate correction for multiple testing applied
  2. bRegression coefficient interpreted as adjusted mean difference in cognitive domain Z-score between Preoperative Depression and No Preoperative Depression groups