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Table 2 Regression analysis evaluating for any relationship between depression at the time of cardiac surgery and postoperative change in domain specific neuropsychological test results. Analysis is adjusted for sex, age, education, baseline cognitive domain z-score, parent study randomized blood pressure management treatment arm, diabetes, obesity, prior stroke, hypertension, atrial fibrillation, and COPD. A negative regression coefficient indicates worse performance for patients with depression compared with those without depression. The “N” represents the number of patients with complete data for the specific domain and covariates included in the model. The results remained consistent in multiple imputation models

From: Postoperative but not preoperative depression is associated with cognitive impairment after cardiac surgery: exploratory analysis of data from a randomized trial

Cognitive Domain

N*

No Preoperative Depression

Preoperative Depression

Regression Coefficientb

Standard Error

P-Valuea

Mean (SD)

Mean (SD)

Attention

209

0.53 (1.01)

0.67 (1.14)

-0.02

0.19

0.944

Memory

209

0.23 (0.67)

0.23 (0.69)

-0.02

0.13

0.944

Visuoconstruction

200

-0.07 (0.84)

-0.03 (0.96)

0.01

0.17

0.944

Verbal Fluency

200

-0.07 (0.57)

-0.07 (0.60)

0.04

0.12

0.944

Processing Speed

202

0.01 (0.67)

-0.02 (1.22)

-0.15

0.16

0.852

Executive Function

183

-0.10 (0.59)

0.22 (0.60)

0.19

0.13

0.439

Fine Motor Speed

183

0.07 (0.56)

-0.07 (1.19)

-0.29

0.15

0.329

  1. aFalse discovery rate correction for multiple testing applied
  2. bRegression coefficient interpreted as adjusted mean difference in change in cognitive domain Z-score between Preoperative Depression and No Preoperative Depression groups