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Table 3 Risk factors for RBC transfusion (logistic regression stratified by centre, stepwise backward elimination)

From: The impact of iron store on red blood cell transfusion: a multicentre prospective cohort study in cardiac surgery

 

Univariable

Multivariable

OR

CI 95%

p value

OR

CI 95%

P-value

Baseline characteristics

  SAPS II (per point)

1.06

1.03–1.08

 < 0.001

1.04

1.02–1.06

0.001

  Age (per year)

1.02

1–1.04

0.031

   

  Sex (male)

0.28

0.19–0.43

 < 0.001

0.23

0.14–0.39

 < 0.001

  BMI (per kg m−2)

0.95

0.91–1

0.031

0.94

0.89–0.99

0.016

Comorbidities

  ASA score (per class)

1.8

1.06–3.05

0.029

   

  Smoking

0.76

0.51–1.13

0.18

   

  Hypertension

1.48

0.97–2.24

0.066

1.53

0.94–2.49

0.09

  Dyslipidaemia

0.93

0.63–1.38

0.73

   

  Arteritis

1.57

0.83–2.96

0.16

   

  Angina

0.89

0.58–1.36

0.59

   

  CRF

1.98

1.15–3.41

0.014

   

  Obstructive lung disease

1.29

0.72–2.31

0.40

   

  Diabetes

0.88

0.53–1.46

0.62

   

  Atrial fibrillation

1.49

0.84–2.64

0.17

   

  NYHA class (per class)

1.63

1.22–2.18

 < 0.001

1.34

0.97–1.87

0.079

  LVEF (per %)

0.98

0.96–1

0.014

0.97

0.95–0.99

0.005

  Pulmonary hypertension

1.74

1–3.03

0.049

   

  Active antiplatelet therapy

1.13

0.77–1.68

0.53

   

Surgery characteristics

  Urgent surgery (vs elective)

1.76

0.97–3.2

0.065

   

  Reoperation

4.85

1.6–14.75

0.005

7.26

1.99–26.39

0.003

  Type of surgery

      

  Isolated valve

REF

REF

REF

REF

REF

REF

  Coronary bypass

0.91

0.58–1.44

0.69

1.46

0.85–2.51

0.168

  Combined surgery

1.80

1.04–3.13

0.036

2.66

1.40–5.06

0.003

  Others

2.26

0.93–5.31

0.062

2.64

0.99–7.04

0.053

Biological statusa

  Serum ferritin < 100 ng ml−1

0.86

0.55–1.35

0.51

0.70

0.42–1.16

0.17

  Serum ferritin 100–300 ng ml−1 and Tsat < 20%

1.52

0.99–2.34

0.058

1.11

0.67–1.84

0.69

  Iron deficiency

1.20

0.81–1.78

0.37

0.85

0.53–1.36

0.49

  Anaemia

3.96

2.41–6.51

 < 0.001

4.16

2.34–7.35

 < 0.001

  1. ASA American Society of Anesthesiologists, BMI body mass index, CPB cardiopulmonary bypass, CRF chronic renal failure defined by a glomerular filtration rate < 60 ml min−1 1.73 m−2. LVEF left ventricular ejection fraction, NYHA New York Heart Association classification for dyspnoea. OR odd ratio, RBC red blood cells, SAPS II Simplified Acute Physiology Score 2, Tsat transferrin saturation
  2. aEach status was tested alone, one by one, in the multivariable analysis