Fig. 4
Surgery could upregulate APP protein in hippocampal samples from animals on the 1st, 3rd and 7th day following surgery (A-C). The agomir-320 could upregulate APP protein in the hippocampus of aged rats on the 1st, 3rd and 7th day following surgery. The injection with antagomir-320 following splenectomy could deregulate APP protein in the hippocampus of aged rats on the 1st, 3rd and 7th day following surgery. There was no significant differences in the expression levels of IGF-1 in hippocampal samples on the 1st, 3rd and 7th day following surgery. *Significant at P≤0.05 for Groups AS, NS, AG, AT versus Groups C , †Significant at P≤0.05 for Group AG versus Group AS. #Significant at P≤0.05 for Groups AT versus Groups AS ,&Significant at P≤0.05 for Groups AT versus Groups AG