Fig. 3
Open Field Test. Compared with the group C, there was no significant statistical difference in the total exercise distance of the rat on the 1st, 3rd and 7th day following surgery (A)(P> 0.05). The morris water maze (MWM) . The escape latency (B) was higher and the ratio of time spent in the target quadrant (C) was lower in Group AS, NS, AG and AT, indicating that cognitive function (ie, spatial learning and memory) decreased in aged rats after surgery (all P <0.05). The escape latency (B) was higher and the ratio of time spent in the target quadrant (C) was lower in the Group AG than those in Group AS (both P<0.05). The escape latency (B) was lower and the ratio of time spent in the target quadrant (C) was higher in the Group AT than those in Group AS (both P <0.05). The escape latency (B) was higher and the ratio of time spent in the target quadrant (C) was lower in the Group AT than in Group AG (both P<0.05), indicating that the antagomir-320 alleviated this impairment. *Significant at P≤0.05 for Groups AS,NS,AG,AT versus Groups C , +Significant at P≤0.05 for Group AG versus Group AS. #Significant at P≤0.05 for Groups AT versus Groups AS ,&Significant at P≤0.05 for Groups AT versus Groups AG