Table 3 Univariable analysis of postoperative fentanyl consumption (Welch’s t-test)
Fentanyl consumption, mean (SD), ln [mcg/kg/day] | 95% CI (lower, upper) | P-value | |
|---|---|---|---|
Sex | |||
Male, n = 130 | 3.34 (0.443) | 3.27, 3.42 | 0.323 |
Female, n = 49 | 3.27 (0.464) | 3.13, 3.40 | |
Diagnosis | |||
Ulcerative colitis, n = 58 | 3.46 (0.423) | 3.35, 3.58 | 0.003 |
Crohn’s disease, n = 121 | 3.26 (0.447) | 3.18, 3.34 | |
Current smoking | |||
Yes, n = 23 | 3.57 (0.431) | 3.39, 3.76 | 0.006 |
No, n = 156 | 3.29 (0.441) | 3.22, 3.36 | |
Coagulopathy | |||
Yes, n = 149 | 3.34 (0.427) | 3.28, 3.41 | 0.246 |
No, n = 30 | 3.22 (0.540) | 3.02, 3.42 | |
Bronchial asthma | |||
Yes, n = 7 | 3.58 (0.184) | 3.41, 3.75 | 0.007 |
No, n = 172 | 3.31 (0.454) | 3.24, 3.38 | |
Diabetes mellitus | |||
Yes, n = 6 | 2.87 (0.346) | 2.51, 3.24 | 0.020 |
No, n = 173 | 3.34 (0.445) | 3.27, 3.41 | |
Hypertension | |||
Yes, n = 6 | 3.27 (0.560) | 2.68, 3.85 | 0.809 |
No, n = 173 | 3.33 (0.446) | 3.26, 3.39 | |
Ischemic heart disease | |||
Yes, n = 2 | 3.32 (0.290) | 0.71, 5.92 | 0.973 |
No, n = 177 | 3.32 (0.451) | 3.26, 3.39 | |
Cerebrovascular disease | |||
Yes, n = 2 | 2.87 (0.007) | 2.80, 2.93 | < 0.001 |
No, n = 177 | 3.33 (0.449) | 3.26, 3.40 | |
Anesthesia maintenance | |||
Volatile, n = 130 | 3.37 (0.438) | 3.29, 3.44 | 0.042 |
Intravenous, n = 49 | 3.21 (0.463) | 3.08, 3.34 | |
Peripheral nerve block | |||
Yes, n = 138 | 3.32 (0.442) | 3.24, 3.39 | 0.658 |
No, n = 41 | 3.35 (0.475) | 3.20, 3.50 | |
Supraumbilical extension of the incision | |||
Yes, n = 59 | 3.22 (0.460) | 3.10, 3.34 | 0.036 |
No, n = 120 | 3.37 (0.436) | 3.30, 3.45 | |
Preoperative use of non-opioid analgesics | |||
Yes, n = 70 | 3.41 (0.468) | 3.30, 3.52 | 0.050 |
No, n = 109 | 3.27 (0.430) | 3.19, 3.35 | |
Preoperative use of opioids | |||
Yes, n = 20 | 3.53 (0.488) | 3.30, 3.75 | 0.059 |
No, n = 159 | 3.30 (0.439) | 3.23, 3.37 | |
Supplementary use of analgesics | |||
Yes, n = 105 | 3.34 (0.442) | 3.26, 3.43 | 0.432 |
No, n = 74 | 3.29 (0.460) | 3.19, 3.40 | |
Medical treatment during the month before surgery | |||
Steroids | |||
Yes, n = 46 | 3.40 (0.383) | 3.29, 3.51 | 0.145 |
No, n = 133 | 3.30 (0.468) | 3.22, 3.38 | |
5-Aminosalicylic acids | |||
Yes, n = 127 | 3.31 (0.443) | 3.23, 3.39 | 0.544 |
No, n = 52 | 3.36 (0.466) | 3.23, 3.49 | |
Immunosuppressants | |||
Yes, n = 52 | 3.37 (0.424) | 3.25, 3.49 | 0.373 |
No, n = 127 | 3.31 (0.459) | 3.22, 3.39 | |
Biologics | |||
Yes, n = 33 | 3.58 (0.459) | 3.42, 3.74 | < 0.001 |
No, n = 146 | 3.27 (0.427) | 3.20, 3.34 | |
Apheresis | |||
Yes, n = 17 | 3.39 (0.364) | 3.20, 3.58 | 0.442 |
No, n = 162 | 3.32 (0.457) | 3.25, 3.39 | |