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Fig. 3 | BMC Anesthesiology

Fig. 3

From: Posttraumatic midazolam administration does not influence brain damage after experimental traumatic brain injury

Fig. 3

Cerebral inflammation. mRNA expression of the inflammatory markers TNF-α (A), IL-1β (B), IL-6 (C), and iNOS (D) relative to peptidylprolyl isomerase A (PPIA) 72 h after injury. Experimental TBI increased the mRNA expression of all proinflammatory markers. IL-1β mRNA expression was increased by high-dose midazolam, which was abrogated by flumazenil; naive: n = 6 mice, treatment groups: n = 9 mice for the Mida HD and the Mida HD + Fluma group, n = 11 mice for the Mida LD and the vehicle group, ***P < 0.001, *P < 0.05; data are presented as mean ± SD; Mida LD, midazolam low-dose group; Mida HD, midazolam high-dose group; Mida + Fluma, midazolam high-dose plus flumazenil.

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BMC Anesthesiology

ISSN: 1471-2253

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