Table 2 Management of mechanical ventilation in ICU patients stratified by age and gender
Variables | All women (n = 314) | All men (n = 539) | P value | Women < 65 years (n = 120) | Men < 65 years (n = 208) | P value | Women ≥ 65 years (n = 194) | Men ≥ 65 years (n = 331) | P value |
|---|---|---|---|---|---|---|---|---|---|
Modes and parameters at the beginning of MV | |||||||||
Modes of MV | 0.099 | 0.375 | 0.055 | ||||||
VCV | 76 (24.2) | 99 (18.4) | 32 (26.7) | 39 (18.8) | 44 (22.7) | 60 (18.1) | |||
PCV | 28 (8.9) | 72 (13.4) | 11 (9.2) | 20 (9.6) | 17 (8.8) | 52 (15.7) | |||
PSV | 73 (23.2) | 111 (20.6) | 27 (22.5) | 46 (22.1) | 46 (23.7) | 65 (19.6) | |||
SIMV | 19 (6.1) | 27 (5.0) | 5 (4.2) | 15 (7.2) | 14 (7.2) | 12 (3.6) | |||
SIMV+PSV | 113 (36.0) | 223 (41.4) | 42 (35.0) | 86 (41.3) | 71 (36.6) | 137 (41.4) | |||
Others | 5 (1.6) | 7 (1.3) | 3 (2.5) | 2 (1.0) | 2 (1.0) | 5 (1.5) | |||
Parameters setting | |||||||||
Tidal volumes (mL/kg PBW) | 8.20 (7.38, 8.88) | 6.77 (6.07, 7.45) | < 0.001 | 8.25 (7.38, 9.01) | 6.83 (6.32, 7.59) | < 0.001 | 8.07 (7.38, 8.70) | 6.68 (6.07, 7.37) | < 0.001 |
Applied PEEP (cmH2O) | 5 (5, 8) | 6 (5, 8) | 0.298 | 5 (5, 8) | 6 (5, 8) | 0.617 | 6 (5, 8) | 6 (5, 8) | 0.339 |
Peak pressure (cmH2O) | 24 (20, 28) | 24 (20, 28) | 0.604 | 24 (20, 27) | 24 (19, 28) | 0.702 | 24 (20, 28) | 24 (20, 29) | 0.350 |
Plateau pressure (cmH2O) | 17 (13, 21) | 18 (14, 20) | 0.759 | 18 (14, 21) | 18 (13, 20) | 0.634 | 17 (12, 21) | 18 (14, 22) | 0.472 |
Use of sedatives | 258 (82.2) | 452 (83.9) | 0.523 | 104 (86.7) | 176 (84.6) | 0.613 | 154 (79.4) | 276 (83.4) | 0.250 |
Use of analgesics | 196 (62.4) | 334 (62.0) | 0.895 | 90 (75.0) | 149 (71.6) | 0.509 | 106 (54.6) | 185 (55.9) | 0.781 |
Use of NMBs | 11 (3.5) | 23 (4.3) | 0.582 | 5 (4.2) | 8 (3.8) | 1.000 | 6 (3.1) | 15 (4.5) | 0.417 |
Events occurring over the course of MV | |||||||||
Barotrauma a | 8 (2.5) | 6 (1.1) | 0.112 | 4 (3.3) | 3 (1.4) | 0.456 | 4 (2.1) | 3 (0.9) | 0.472 |
VAP | 51 (16.2) | 103 (19.1) | 0.294 | 9 (7.5) | 34 (16.3) | 0.022 | 42 (21.6) | 69 (20.8) | 0.828 |
Self-extubation | 5 (1.6) | 5 (0.9) | 0.589 | 1 (0.8) | 1 (0.5) | 1.000 | 4 (2.1) | 4 (1.2) | 0.688 |
Reintubation | 21 (6.7) | 24 (4.5) | 0.159 | 5 (4.2) | 5 (2.4) | 0.575 | 16 (8.2) | 19 (5.7) | 0.266 |
Tracheotomy | 44 (14.0) | 93 (17.3) | 0.214 | 13 (10.8) | 40 (19.2) | 0.047 | 31 (16.0) | 53 (16.0) | 0.992 |
PMV b | 37 (11.8) | 71 (13.2) | 0.556 | 6 (5.0) | 22 (10.6) | 0.082 | 31 (16.0) | 49 (14.8) | 0.717 |