Table 1 Baseline characteristics of mechanically ventilated ICU patients stratified by age and gender
Variables | All women (n = 314) | All men (n = 539) | P value | Women < 65 years (n = 120) | Men < 65 years (n = 208) | P value | Women ≥ 65 years (n = 194) | Men ≥ 65 years (n = 331) | P value |
|---|---|---|---|---|---|---|---|---|---|
Age (years) | 72 (55, 79) | 72 (55, 80) | 0.546 | 49 (35, 58) | 51 (41, 58) | 0.298 | 78 (73, 82) | 78 (73, 83) | 0.356 |
BMI (kg/m2) | 23 (21, 26) | 23 (21, 25) | 0.156 | 23 (21, 26) | 24 (21, 26) | 0.799 | 23 (20, 26) | 23 (21, 24) | 0.057 |
History of smoking | 30 (9.6) | 271 (50.3) | < 0.001 | 6 (5.0) | 112 (53.8) | < 0.001 | 24 (12.4) | 159 (48.0) | < 0.001 |
Past history of surgery | 82 (26.1) | 133 (24.7) | 0.641 | 35 (29.2) | 52 (25.0) | 0.410 | 47 (24.2) | 81 (24.5) | 0.950 |
NIMV before ICU admission | 36 (11.5) | 66 (12.2) | 0.735 | 14 (11.7) | 27 (13.0) | 0.729 | 22 (11.3) | 39 (11.8) | 0.879 |
Source of ICU admission | |||||||||
Medical ward | 63 (20.1) | 122 (22.6) | 0.380 | 15 (12.5) | 28 (13.5) | 0.804 | 48 (24.7) | 94 (28.4) | 0.363 |
Surgical ward | 145 (46.2) | 252 (46.8) | 0.871 | 64 (53.3) | 113 (54.3) | 0.862 | 81 (41.8) | 139 (42.0) | 0.957 |
Emergency department | 97 (30.9) | 150 (27.8) | 0.342 | 34 (28.3) | 60 (28.8) | 0.921 | 63 (32.5) | 90 (27.2) | 0.198 |
Others | 9 (2.9) | 15 (2.8) | 0.943 | 7 (5.8) | 7 (3.4) | 0.287 | 2 (1.0) | 8 (2.4) | 0.429 |
APACHE II scores | 15 (11, 21) | 17 (11, 23) | 0.227 | 12 (8, 18) | 14 (8, 19) | 0.568 | 18 (13, 24) | 19 (13, 24) | 0.376 |
Comorbidities | |||||||||
Hypertension | 156 (49.7) | 247 (45.8) | 0.277 | 28 (23.3) | 49 (23.6) | 0.963 | 128 (66.0) | 198 (59.8) | 0.160 |
Diabetes | 99 (31.5) | 134 (24.9) | 0.035 | 16 (13.3) | 26 (12.5) | 0.828 | 83 (42.8) | 108 (32.6) | 0.020 |
Chronic renal failure | 40 (12.7) | 57 (10.6) | 0.337 | 10 (8.3) | 15 (7.2) | 0.712 | 30 (15.5) | 42 (12.7) | 0.372 |
Chronic heart failure | 32 (10.2) | 48 (8.9) | 0.534 | 2 (1.7) | 7 (3.4) | 0.578 | 30 (15.5) | 41 (12.4) | 0.320 |
COPD | 29 (9.2) | 56 (10.4) | 0.587 | 3 (2.5) | 5 (2.4) | 1.000 | 26 (13.4) | 51 (15.4) | 0.531 |
Cirrhosis | 1 (0.3) | 10 (1.9) | 0.109 | 1 (0.8) | 6 (2.9) | 0.400 | 0 (0.0) | 4 (1.2) | 0.309 |
Pulmonary fibrosis | 6 (1.9) | 19 (3.5) | 0.178 | 4 (3.3) | 6 (2.9) | 1.000 | 2 (1.0) | 13 (3.9) | 0.054 |
Cancer | 35 (11.1) | 69 (12.8) | 0.476 | 11 (9.2) | 15 (7.2) | 0.528 | 24 (12.4) | 54 (16.3) | 0.220 |
Stroke | 56 (17.8) | 121 (22.4) | 0.109 | 4 (3.3) | 27 (13.0) | 0.004 | 52 (26.8) | 94 (28.4) | 0.694 |
No. of comorbidities | 0.592 | 0.590 | 0.053 | ||||||
None | 91 (29.0) | 174 (32.3) | 70 (58.3) | 112 (53.8) | 21 (10.8) | 62 (18.7) | |||
1 | 88 (28.0) | 147 (27.3) | 31 (25.8) | 54 (26.0) | 57 (29.4) | 93 (28.1) | |||
≥ 2 | 135 (43.0) | 218 (40.4) | 19 (15.8) | 42 (20.2) | 116 (59.8) | 176 (53.2) | |||
Primary indication for MV | |||||||||
ARDS | 30 (9.6) | 47 (8.7) | 0.682 | 16 (13.3) | 16 (7.7) | 0.907 | 14 (7.2) | 31 (9.4) | 0.396 |
Postoperative | 127 (40.4) | 195 (36.2) | 0.215 | 58 (48.3) | 100 (48.1) | 0.964 | 69 (35.6) | 95 (28.7) | 0.101 |
Congestive heart failure | 23 (7.3) | 25 (4.6) | 0.101 | 5 (4.2) | 4 (1.9) | 0.397 | 18 (9.3) | 21 (6.3) | 0.216 |
Aspiration | 4 (1.3) | 15 (2.8) | 0.150 | 0 (0.0) | 3 (1.4) | 0.472 | 4 (2.1) | 12 (3.6) | 0.314 |
Pneumonia | 49 (15.6) | 111 (20.6) | 0.072 | 11 (9.2) | 28 (13.5) | 0.247 | 38 (19.6) | 83 (25.1) | 0.150 |
Sepsis | 14 (4.5) | 34 (6.3) | 0.258 | 7 (5.8) | 15 (7.2) | 0.631 | 7 (3.6) | 19 (5.7) | 0.277 |
Trauma | 0 (0.0) | 11 (2.0) | 0.026 | 0 (0.0) | 9 (4.3) | 0.050 | 0 (0.0) | 2 (0.6) | 0.533 |
Cardiac arrest | 10 (3.2) | 17 (3.2) | 0.980 | 2 (1.7) | 6 (2.9) | 0.751 | 8 (4.1) | 11 (3.3) | 0.636 |
COPD or asthma | 17 (5.4) | 33 (6.1) | 0.671 | 1 (0.8) | 3 (1.4) | 1.000 | 16 (8.2) | 30 (9.1) | 0.750 |
Other chronic pulmonary diseases | 7 (2.2) | 10 (1.9) | 0.706 | 5 (4.2) | 3 (1.4) | 0.242 | 2 (1.0) | 7 (2.1) | 0.565 |
Coma | 22 (7.0) | 18 (3.3) | 0.015 | 9 (7.5) | 10 (4.8) | 0.315 | 13 (6.7) | 8 (2.4) | 0.016 |
Other | 11 (3.5) | 23 (4.3) | 0.582 | 6 (5.0) | 11 (5.3) | 0.910 | 5 (2.6) | 12 (3.6) | 0.513 |
Arterial blood gas analysis prior to MV | |||||||||
pH | 7.36 (7.25, 7.42) | 7.36 (7.25, 7.42) | 0.885 | 7.38 (7.29, 7.44) | 7.36 (7.25, 7.42) | 0.162 | 7.34 (7.23, 7.40) | 7.35 (7.25, 7.42) | 0.200 |
Pao2/FIo2 | 183 (120, 285) | 168 (112, 273) | 0.412 | 194 (117, 319) | 181 (118, 314) | 0.941 | 180 (120, 248) | 160 (110, 255) | 0.268 |
Paco2 (mmHg) | 40 (33, 52) | 40 (34, 52) | 0.790 | 36 (32, 42) | 39 (33, 47) | 0.112 | 42 (34, 64) | 41 (34, 56) | 0.359 |
Spo2 (%) | 95 (89, 100) | 95 (88, 99) | 0.032 | 97 (89, 100) | 95 (90, 99) | 0.142 | 95 (89, 99) | 93 (88, 98) | 0.100 |