Fig. 2

The Pathway-risk model. To construct the Pathway-risk model, two steps (Pathway characteristics screening and model establishing) were conducted. Pathway characteristics screening: 20 prognostic pathways were finally enrolled into the Pathway-risk model after univariate Cox regression analyses, Lasso regression analyses and both backward and forward stepwises selection based on the AIC. Pathway-risk model establishing: The final pathway model was constructed by multivariate Cox regression analyses and generated a pathway risk score for every patient. The forest plots of 20 pathways in multivariate Cox regression analyses. The first column was the name of 20 pathways; the second column showed the sample size; the third column illuminated the HR and 95%CI of 20 pathways; the forth column was the forest plots of HR and 95%CI; the last column indicated the P value of 20 pathways in multivariate Cox regression analyses