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Table 2 Characteristics and physiological parameters of patients in the included studies

From: Unfractionated heparin improves the clinical efficacy in adult sepsis patients: a systematic review and meta-analysis

Article, year APACHE II score P value Intervention 28 d Mortality (%) P value
UFH Control UFH Control UFH Control
Deng et al, 2017 [22] 20.5 ± 4.2 21.8 ± 6.2 P > 0.05 UFH 7d (vein) Usual care 21.7 30.9 P < 0.05
Gu et al, 2014 [23] 12 ± 9 16 ± 5 P > 0.05 UFH 5–10 U/(kg*h) 7d (vein) Usual care 23.8 33.3 P > 0.05
Guo et al, 2019 [24] 15.22 ± 5.34 18.16 ± 5.53 P > 0.05 UFH 70 U/kg 5-7d (vein) Usual care + saline NR NR NR
Hou et al, 2011 [25] 11.8 ± 3.5 15.3 ± 6.4 P > 0.05 UFH 3-4 U/kg/h 7d (vein) Usual care 15 25 P = 0.429 > 0.05
Jaimes et al, 2009 [26] 9 (IQR: 7–13) 10 (IQR: 6–14) P > 0.05 UFH 500 U/h 5-7d (vein) Usual care + saline 14 25 P = 0.652 > 0.05
Levi et al, 2007 [27] 23.8 ± 7.6 24.0 ± 7.4 P = 0.90 > 0.05 UFH 5000 units bid (subcutaneously) Usual care + saline 29.3 31.9 P > 0.05
Liu et al, 2014 [28] 20.82 ± 6.5 21.0 ± 6.69 P = 0.935 > 0.05 UFH 70 U/kg/24 h 5-7d (vein) Usual care + saline 31.8 40 P = 0.434 > 0.05
Liu et al, 2009 [29] 12.67 ± 4.27 15.73 ± 7.27 P = 0.708 > 0.05 UFH 70 U/kg/24 h 5-7d (vein) Usual care + saline 33.3 36.4 P = 0.643 > 0.05
Peng et al, 2013 [30] 15.22 ± 5.34 18.46 ± 5.53 P > 0.05 UFH 70 U/kg/24 h 5-7d (vein) Usual care + saline 12.5 28.6 P < 0.05
Wang et al, 2012 [31] 18.7 ± 6.9 15.2 ± 6.2 P > 0.05 UFH 3-4 U/kg/h 7d (vein) Usual care 8.33 12.5 P > 0.05
Wu et al, 2011 [32] 16.69 ± 4.12 18.89 ± 5.23 P = 0.684 > 0.05 UFH 5 U/kg/h 7d (vein) Usual care 17.78 37.5 P < 0.05
Zhang et al, 2006 [33] NR NR P > 0.05 UFH 3-4 U/kg/h 7d (vein) Usual care 27.3 27.3 P < 0.05
Zhao et al, 2009 [34] 14.5 ± 4.2 14.8 ± 6.2 P > 0.05 UFH 40-50 mg/kg/24 h 5-7d (vein) Usual care 15.4 32.4 P = 0.03 < 0.05
Zhao et al, 2007 [35] 20.54 ± 4.8 18.19 ± 3.69 P > 0.05 UFH 300 U/h 5d (vein) Usual care + saline 33.3 48 P > 0.05
Zhang et al, 2016 [36] 11.7 ± 3.1 13.7 ± 7.6 P > 0.05 UFH 5 U/kg/h 7d (vein) Usual care NR NR NR
  1. NR not reported, UFH unfractionated heparin, APACHE II Acute Physiology and Chronic Health Evaluation II, IQR interquartile range