Table 2 Characteristics and physiological parameters of patients in the included studies

Deng et al, 2017 [22]

20.5 ± 4.2

21.8 ± 6.2

P > 0.05

UFH 7d (vein)

Usual care

21.7

30.9

P < 0.05

Gu et al, 2014 [23]

12 ± 9

16 ± 5

P > 0.05

UFH 5–10 U/(kg*h) 7d (vein)

Usual care

23.8

33.3

P > 0.05

Guo et al, 2019 [24]

15.22 ± 5.34

18.16 ± 5.53

P > 0.05

UFH 70 U/kg 5-7d (vein)

Usual care + saline

NR

NR

NR

Hou et al, 2011 [25]

11.8 ± 3.5

15.3 ± 6.4

P > 0.05

UFH 3-4 U/kg/h 7d (vein)

Usual care

15

25

P = 0.429 > 0.05

Jaimes et al, 2009 [26]

9 (IQR: 7–13)

10 (IQR: 6–14)

P > 0.05

UFH 500 U/h 5-7d (vein)

Usual care + saline

14

25

P = 0.652 > 0.05

Levi et al, 2007 [27]

23.8 ± 7.6

24.0 ± 7.4

P = 0.90 > 0.05

UFH 5000 units bid (subcutaneously)

Usual care + saline

29.3

31.9

P > 0.05

Liu et al, 2014 [28]

20.82 ± 6.5

21.0 ± 6.69

P = 0.935 > 0.05

UFH 70 U/kg/24 h 5-7d (vein)

Usual care + saline

31.8

40

P = 0.434 > 0.05

Liu et al, 2009 [29]

12.67 ± 4.27

15.73 ± 7.27

P = 0.708 > 0.05

UFH 70 U/kg/24 h 5-7d (vein)

Usual care + saline

33.3

36.4

P = 0.643 > 0.05

Peng et al, 2013 [30]

15.22 ± 5.34

18.46 ± 5.53

P > 0.05

UFH 70 U/kg/24 h 5-7d (vein)

Usual care + saline

12.5

28.6

P < 0.05

Wang et al, 2012 [31]

18.7 ± 6.9

15.2 ± 6.2

P > 0.05

UFH 3-4 U/kg/h 7d (vein)

Usual care

8.33

12.5

P > 0.05

Wu et al, 2011 [32]

16.69 ± 4.12

18.89 ± 5.23

P = 0.684 > 0.05

UFH 5 U/kg/h 7d (vein)

Usual care

17.78

37.5

P < 0.05

Zhang et al, 2006 [33]

NR

NR

P > 0.05

UFH 3-4 U/kg/h 7d (vein)

Usual care

27.3

27.3

P < 0.05

Zhao et al, 2009 [34]

14.5 ± 4.2

14.8 ± 6.2

P > 0.05

UFH 40-50 mg/kg/24 h 5-7d (vein)

Usual care

15.4

32.4

P = 0.03 < 0.05

Zhao et al, 2007 [35]

20.54 ± 4.8

18.19 ± 3.69

P > 0.05

UFH 300 U/h 5d (vein)

Usual care + saline

33.3

48

P > 0.05

Zhang et al, 2016 [36]

11.7 ± 3.1

13.7 ± 7.6

P > 0.05

UFH 5 U/kg/h 7d (vein)

Usual care

NR

NR

NR