Table 1 The basic characteristics of the included studies

Deng et al, 2017 [22]

1

118,

62/56

Sepsis and septic shock

62.5 ± 13.9

61.5 ± 15.2

P > 0.05

Gu et al, 2014 [23]

1

42,

21/21

Sever sepsis

64.6 ± 12.7

69.7 ± 16.3

P > 0.05

Guo et al, 2019 [24]

1

90,45/45

Sepsis with pre-DIC

64.75 ± 7.88

68.87 ± 6.16

P > 0.05

Hou et al, 2011 [25]

1

40,

20/20

Sever sepsis

58.6 ± 15.4

57.7 ± 12.6

P > 0.05

Jaimes et al, 2009 [26]

1

319,

159/160

Sepsis

57 (IQR: 39–70)

55 (IQR: 40–72)

P > 0.05

Levi et al, 2007 [27]

224

1440,

485/955

Sever sepsis

59.6 ± 16.1

58.4 ± 16.0

P = 0.90 > 0.05

Liu et al, 2014 [28]

1

37,

22/15

Sepsis

48.86 ± 14.3

47.47 ± 14.68

P = 0.935 > 0.05

Liu et al, 2009 [29]

1

27,

12/15

Sepsis

47.4 ± 16.8

48.3 ± 14.1

P = 0.708 > 0.05

Peng et al, 2013 [30]

1

112,

56/56

Sepsis with pre-DIC

63.5 ± 7.8

63.5 ± 7.8

P > 0.05

Wang et al, 2012 [31]

1

48,

24/24

Sepsis

52.7 ± 9.4

54.3 ± 8.6

P > 0.05

Wu et al, 2011 [32]

1

85,

45/40

Sepsis

68 ± 13

67 ± 14

P = 0.684 > 0.05

Zhang et al, 2006 [33]

1

22,

11/11

Sever sepsis

59.55 ± 6.15

59.36 ± 8.05

P > 0.05

Zhao et al, 2009 [34]

1

79,

37/42

Sepsis

61.5 ± 11.9

60.6 ± 15.9

P > 0.05

Zhao et al, 2007 [35]

1

52,

27/25

Sever sepsis

NR

NR

P > 0.05

Zhang et al, 2016 [36]

1

106,

53/53

Sepsis

43.5 ± 6.6

43.5 ± 6.6

P > 0.05