Table 1 Patient demographic data, hemodynamic, respiratory, pharmacological and biological variables at baseline in Responders (n = 9) and Non-Responders (n = 9 patients)
Overall population | Responders | Non-Responders | p value | |
|---|---|---|---|---|
N = 18 | N = 9 | N = 9 | ||
Age (mean SD), yr | 60 (15) | 66 (7) | 57 (18) | |
Gender (M/F) | 10/8 | 5/4 | 5/4 | |
BMI (mean SD), kg.m-2 | 29 (9) | 29 (6) | 29 (12) | |
Ideal body weight (mean SD), kg | 66 (14) | 63 (11) | 66 (17) | |
SAPS 2 (mean SD) | 61 (22) | 69 (22) | 57 (21) | |
ICU admission criteria | ||||
Septic shock | 4 | 3 | 1 | |
Cardiac failure | 7 | 3 | 4 | |
Respiratory failure | 4 | 2 | 2 | |
Hemorrhagic shock | 1 | 1 | 0 | |
Polytrauma | 1 | 0 | 0 | |
Cranio-cerebral trauma | 1 | 0 | 1 | |
Comorbidities | ||||
Arterial hypertension | 8 | 6 | 2 | |
Diabetes | 4 | 2 | 2 | |
Coronary artery disease | 1 | 1 | 0 | |
Hemodynamic parameters | ||||
Mean arterial pressure (mean SD), mmHg | 73 (9) | 70 (10) | 76 (7) | 0.110 |
Heart Rate (mean SD), HR/min | 90 (18) | 91 (23) | 87 (11) | 0.813 |
Stroke volume (mean SD), mL | 62 (26) | 53 (20) | 64 (29) | 0.177 |
Cardiac output (mean SD), L/min | 5.3 (2.2) | 4.5 (1.0) | 5.5 (2.7) | 0.150 |
PPV (mean SD), % | 10 (8) | 14 (10) | 6 (2) | 0.034 |
Central Venous Pressure (mean SD), mmHg | 10 (4) | 9 (3) | 10 (4) | 0.238 |
Respiratory parameters | ||||
Tidal volume (mean SD), mL | 436 (62) | 452 (55) | 405 (68) | 0.288 |
Respiratory Rate (mean SD), RR/min | 20 (5) | 18 (4) | 22 (6) | 0.218 |
Positive end expiratory pressure (mean SD), cmH2O | 10 (3) | 9 (2) | 10 (3) | 0.671 |
Plateau pressure (mean SD), cmH2O | 22 (6) | 19 (3) | 23 (8) | 0.099 |
Static pulmonary compliance (mean SD), mL/cmH2O | 42 (15) | 48 (11) | 37 (15) | 0.065 |
P/F (mean SD) | 236 (97) | 224 (104) | 242 (97) | 0.679 |
Neuromuscular blockade, n | 9 | 4 | 5 | |
Pharmacological parameters | ||||
Norepinephrine (mean SD), ug/kg/min | 0.50 (0.64) | 0.78 (0.76) | 0.24 (0.35) | 0.031 |
Dobutamine (mean SD), ug/kg/min | 2.06 (3.37) | 1.44 (2.96) | 2.67 (3.81) | 0.394 |
Biological parameters | ||||
Lactates (mean SD), mmol/l | 2.2 (1.5) | 2.7 (2.1) | 2.0 (0.8) | 0.215 |