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Table 4 Summary of TE arrhythmias analyzed by NMBA stratum. All Participants as Treated

From: A randomized trial evaluating the safety profile of sugammadex in high surgical risk ASA physical class 3 or 4 participants

Treatment

Rocuronium

Vecuronium

n (%)

Estimate (95% CI)

P-value

n (%)

Estimate (95% CI)

P-value

TE Sinus Bradycardia

 Neostigmine/glycopyrrolate, n = 32a, 19b

3 (9.4)

(ref.)

 

2 (15.4)

(ref.)

 

  Sugammadex 2 mg/kg, n = 65a, 40b

0

−9.4 (−24.3, −3.2)

0.013

0

−2.8 (− 22.6, 8.7)

0.587

 Sugammadex 4 mg/kg, n = 66a, 41b

2 (3.0)

−6.3 (− 21.6, 3.0)

0.183

1 (3.6)

−5.3 (− 24.9, 3.8)

0.142

 Sugammadex 16 mg/kg, n = 68a

5 (7.4)

− 2.0 (− 17.7, 8.9)

0.729

N/A

N/A

N/A

TE Sinus Tachycardia

 Neostigmine/glycopyrrolate, n = 32a, 19b

6 (18.8)

(ref.)

 

4 (30.8)

(ref.)

 

 Sugammadex 2 mg/kg, n = 65a, 40b

6 (9.2)

−9.5 (−27.2, 4.2)

0.183

2 (7.7)

−23.8 (−46.9, −7.1)

0.005

 Sugammadex 4 mg/kg, n = 66a, 41b

7 (10.6)

−8.1 (− 25.9, 5.8)

0.267

0

−19.0 (− 42.7, −0.3)

0.046

 Sugammadex 16 mg/kg, n = 68a

6 (8.8)

− 9.9 (− 27.5, 3.5)

0.156

N/A

N/A

N/A

Other TE Cardiac Arrhythmias

 Neostigmine/glycopyrrolate, n = 32a, 19b

1 (3.1)

(ref.)

 

1 (7.7)

(ref.)

 

 Sugammadex 2 mg/kg, n = 65a, 40b

0

−3.1(−15.8, 2.6)

0.154

1 (3.8)

2.5 (−14.7, 13.0)

0.491

 Sugammadex 4 mg/kg, n = 66a, 41b

0

−3.1 (− 15.8, 2.5)

0.151

0

0.0 (−17.1, 8.7)

> 0.999

 Sugammadex 16 mg/kg, n = 68a

1 (1.5)

−1.7 (− 14.5, 5.3)

0.583

N/A

N/A

N/A

  1. aNumber of participants in rocuronium stratum; bNumber of participants in vecuronium stratum; CI Confidence interval, N/A Not applicable, NMBA Neuromuscular blocking agent, TE Treatment-emergent