Fig. 7
From: Comparative analysis of the effects of opioids in angiogenesis
Morphine but not fentanyl or oxycodone acts on HUVEC via MAPK activation. Western blots (A) and quantification of band intensity (B) of HUVEC exposed to morphine, fentanyl, oxycodone or codeine for 6 h. MAPK inhibitor PD98059 (1 μM) significantly reversed the effects of morphine but not fentanyl or oxycodone in stimulating capillary network formation (B), increasing proliferation (C) and decreasing apoptosis (D) in HUVEC. Results shown are relative to control. Each experiment was repeated three times in triplicate, and each value indicates mean ± SD. *p < 0.05, compared to -PD98059. ns, not significant. Relevant blot images were cropped to improve clarity