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Table 1 characteristics of patients who remained hospitalized in the ICU at 24 h following sepsis onset, summarized by intubation requirement

From: Outcome after intubation for septic shock with respiratory distress and hemodynamic compromise: an observational study

Variable

Non-intubated within 24 h (N = 707)

Intubated within 24 h (N = 345)

P Value

Age (y)

69.5

(59.4, 80.2)

66.0

(55.4, 74.2)

< 0.001

Sex

    

0.24

 Male

383

(54)

200

(58)

 

  Female

324

(32)

145

(33)

 

BMI (kg/m2), n = 701/339

28.2

(23.6, 34.5)

28.5

(24.5, 35.1)

0.18

ICU admission source

    

0.007

  Emergency Department

328

(32)

134

(34)

 

  Direct admit (from an outside facility)

249

(35)

156

(36)

 

  Transfer from the floor

130

(18)

55

(16)

 

APACHE III score

68

(57, 82)

92

(74, 115)

< 0.001

SOFA score (day 1)

6

(4,8)

10

(8,13)

< 0.001

SOFA score (day 2), n = 589/334

4

(2,7)

7

(4,10)

< 0.001

Failed to resolve within 6 h per MAP

113

(16)

30

(9)

0.001

Failed to resolve within 6 h per lactate

230

(37)

137

(38)

0.022

Non-invasive ventilation use

108

(15)

62

(18)

0.26

Days on invasive ventilation, n = 153/345

0.8

(0.3, 2.0)

2.3

(1.1, 4.8)

< 0.001

ICU mortality

37

(5)

59

(17)

< 0.001

ICU length of stay (d), n = 670/286

2.0

(1.3, 3.1)

3.7

(2.3, 6.9)

< 0.001

Hospital mortality

82

(12)

89

(26)

< 0.001

Hospital length of stay (d), n = 625/256

6.8

(4.5, 11.4)

10.3

(6.6, 20.6)

< 0.001

  1. Continuous variables are summarized as median (Q1, Q3) and compared using rank-sum tests. Categorical variables are summarized as n (%) and compared using Chi-squared tests. ICU and hospital length of stay are summarized only for patients who were discharged alive from the ICU and hospital respectively. When information is missing, the number of observations with complete data is presented. Abbreviations: ICU = Intensive Care Unit; APACHE III = Acute Physiology and Chronic Health Evaluation III; SOFA + Sequential Organ Failure Assessment; BMI = Body Mass Index; MAP = Mean Arterial Pressure