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Table 4 Predictors of myocardial injury

From: Prevalence and risk factors of myocardial and acute kidney injury following radical nephrectomy with vena cava thrombectomy: a retrospective cohort study

 

Univariable analysis a

 

Multivariable analysis b

 

OR (95% CI)

P value

OR (95% CI)

P value

Age, year

0.97 (0.95, 1.00)

0.069

–

–

Male sex

0.43 (0.20, 0.92)

0.029

0.27 (0.10, 0.71)

0.008

ASA class (III + IV vs. I + II)

  

–

–

 I + II

Ref

 

–

–

 III + IV

1.94 (0.94, 4.02)

0.075

–

–

Mayo classification

 I + II

Ref

 

Ref

–

 III + IV

8.18 (3.18, 21.1)

< 0.001

4.21 (1.42, 12.4)

0.009

Use of nitrous oxide during anesthesia

0.46 (0.22, 0.95)

0.037

–

–

Acute normovolemic hemodilution before surgery

2.21 (1.09, 4.48)

0.028

2.66 (1.10, 6.41)

0.029

Duration of intraoperative hypotension, 20 min

1.37 (1.11, 1.69)

0.004

–

–

Duration of intraoperative tachycardia, 20 min

1.73 (1.18, 2.53)

< 0.001

1.49 (1.03, 2.16)

0.036

Intraoperative bradycardia

2.99 (1.26, 7.06)

0.013

–

–

Intraoperative allogeneic blood transfusion

5.25 (2.40,11.49)

< 0.001

–

–

Complete IVC clamping during surgery

3.62 (1.17, 11.26)

0.026

–

–

Duration of surgery, h

1.71 (1.37, 2.12)

< 0.001

1.48 (1.03, 2.16)

0.009

Use of NSAIDs during perioperative period

0.19 (0.09, 0.42)

< 0.001

–

–

  1. Preoperative abnormal kidney function and Charlson Comorbidity Index were excluded because of correlation with ASA class
  2. Intraoperative lowest hemoglobin was excluded because of correlation with intraoperative allogeneic blood transfusion
  3. Intraoperative hypotension and intraoperative highest lactic acid were excluded because of correlation with duration of intraoperative hypotension
  4. Intraoperative tachycardia was excluded because of correlation with duration of intraoperative tachycardia
  5. Duration of anesthesia, volume of fluid infusion, intraoperative infusion balance and urine output were excluded because of correlation with duration of surgery
  6. Colloid fluid, fresh frozen plasma and platelet concentrate were excluded because of correlation with the allogeneic blood transfusion
  7. Hepatic hilum clamping and use of cardiopulmonary bypass during surgery and duration of cardiopulmonary bypass were excluded because of correlation with the Mayo classification of tumor thrombus
  8. a Myocardial injury was modeled as a function of a single factor in the univariable logistic regression analysis
  9. b Myocardial injury was modeled as a function of all factors with a P value < 0.2 in the univariate analysis or those that were considered clinically important. Multivariable analysis was performed using the backward method. Hosmer-Lemeshow test of goodness of fit of the model: χ2 = 3.135, df = 8, P = 0.926