Fig. 2
Estimation of probabilities of UMSS score. 2A depicts the estimation of the probability that the University of Michigan Sedation Scale (UMSS) score is n or more (n = 1, 2, 3, 4) according to the effect-site concentration (Ce) of propofol. Probabilities were calculated for Ce50UMSS ≥ n with a pharmacodynamic model using the Laplace method. 2B shows the probability for each specific UMSS score according to Ce of propofol. Detailed calculation methods are presented in the methods section. The probabilities for UMSS scores = 1, 2, and 3 show a single peak, and the probability of UMSS score = 4 shows a gradual increase as the Ce of propofol increases. Ce50UMSS ≥ n, the steady-state effect-site concentration of propofol with a 50% probability of UMSS score being equal to or greater than n