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Table 2 Comparison of EC50 and EC90 values of CMGCD and sugammadex

From: Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study

NMBA

SRBA

EC50 (μM)

EC90 (μM)

Rocuronium

CMGCD

35.89 (32.67–39.41)

119.9 (101.5–141.9)

Sugammadex

3.67 (3.43–3.92)

6.08 (5.34–6.92)

Pipecuronium

CMGCD

10.14 (9.61–10.70)

21.60 (19.63–23.76)

Sugammadex

0.67 (0.62–0.74)

1.05 (0.86–1.29)

Vecuronium

CMGCD

376.1 (341.9–413.8)

863.1 (727.8–1023)

Sugammadex

1.45 (1.35–1.56)

3.33 (2.82–3.92)

  1. Values are given as mean and 95% confidence interval. EC50, effective concentration for 50% effect; EC90, effective concentration for 90% effect. CMGCD Carboxymethyl-γ-cyclodextrin