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Table 7 Blood samples, stratified according to HTV-l.PEEP versus LTV-h.PEEP

From: Hemodynamic, renal and hormonal effects of lung protective ventilation during robot-assisted radical prostatectomy, analysis of secondary outcomes from a randomized controlled trial

 

Blood 1 (Baseline)

Blood 2 (Surgery, 1 h)

Blood 3 (Surgery, end)

Blood 4 (Day 1)

Blood 5 (Day 2)

Blood 6 (Day 7)

P-value1

P-value2

P-renin (pg/ml)

9 [5;17]

39 [15; 66]*

48 [15;78]*

13 [8.0;19]*

8 [6;16]

11 [5;26]

< 0.0001

 

HTV-l.PEEP

9 [6; 14]

44 [18;60]*

46 [15;58]*

12 [8;16]*

8 [6;15]

11 [4;23]

< 0.0001

0.821

LTV-h.PEEP

9 [5;20]

34 [13;70]*

57 [16;115]*

13 [9;30]

8 [6;16]

10 [5;44]

< 0.0001

P

0.640

0.899

0.326

0.659

0.723

0.600

  

P-angiotensin II (pg/ml)

5 [4;7]

34 [11;74]*

34 [15;87]*

8 [5;13]*

6 [4;7]

5 [4;15]*

< 0.0001

 

HTV-l.PEEP

5 [4;8]

42 [17;69]*

46 [15;68]*

10 [6;14]*

7 [5;7]

10 [4;15]

< 0.0001

0.993

LTV-h.PEEP

5 [3;7]

14 [9;79]*

25 [16;117]*

7 [5;10]*

4 [4;7]

5 [4;13]

< 0.0001

P

0.373

0.370

0.681

0.338

0.247

0.677

  

P-aldosterone (pmol/l)

250 [196;320]

457 [344;527]*

433 [256;557]*

220 [169;295]

222 [178;269]

251 [204;357]

< 0.0001

 

HTV-l.PEEP

220 [185;279]

417 [289;500]*

329 [229.;467]*

221 [169;273]

219 [178;249]

222 [204;279]

0.014

0.425

LTV-h.PEEP

284 [223;374]

476 [374;570]*

516 [313;603]*

218 [177;310]*

229 [176;292]

301 [213;397]

0.003

P

0.097

0.347

0.128

0.966

0.767

0.164

  

P-vasopressin (pg/ml)

0.3 [0.2;0.3]

0.3 [0.3;0.4]*

0.4 [0.3;0.5]*

0.4 [0.3;0.5]*

0.4 [0.3;0.6]*

0.3 [0.3;0.3]

0.0001

 

HTV-l.PEEP

0.3 [0.2;0.3]

0.3 [0.3;0.5]*

0.4 [0.3;0.6]*

0.4 [0.4;0.5]*

0.4 [0.3;0.6]*

0.3 [0.3;0.4]*

0.0004

0.999

LTV-h.PEEP

0.3 [0.2;0.3]

0.3 [0.3;0.3]

0.3 [0.2;0.4]

0.3 [0.3;0.5]

0.3 [0.3;0.5]

0.3 [0.2;0.3]

0.099

P

0.947

0.473

0.127

0.138

0.315

0.045

  

P-brain natriuretic peptide (pmol/l)

5.4 [2.9;10.8]

6.6 [3.6;10.6]*

7.6 [4.3;11.3]*

7.8 [4.3;13.1]*

5.9 [4.2;10.7]

4.3 [2.9;9.0]

0.001

 

HTV-l.PEEP

5.4 [2.9;11.1]

6.9 [3.5;10.6]*

8.0 [4.4;11.3]*

9.5 [3.0;12.0]

4.2 [2.9;7.15]

3.2 [2.9;4.2]

0.003

0.319

LTV-h.PEEP

4.8 [3.3;8.5]

6.2 [3.7;12.9]*

7.3 [3.9;11.9]*

7.3 [5.2;16.5]*

8.1 [5.8;14.3]*

7.2 [4.5;13.5]

0.030

P

0.845

0.811

0.854

0.712

0.018

0.033

  
  1. HTV-l.PEEP High tidal volume, low positive end-expiratory pressure, LTV-h.PEEP Low tidal volume, low positive end-expiratory pressure
  2. All data considered non-normally distributes; shown as medians [25–75% quartiles]; Wilcoxon signed rank test used to test difference from baseline, * = p < 0.05; Mann-Whitney U test used to test difference between groups
  3. 1P-value showing the difference in medians within groups analyzed by Friedmann test
  4. 2P-value showing the difference in medians between groups analyzed by generalized linear model
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BMC Anesthesiology

ISSN: 1471-2253

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