| | Phenylephrine (P) | Norepinephrine (N) | Metaraminol (M) | Vasopressin (V) | P value |
|---|
P vs. N | M vs. N | V vs. N |
|---|
Uterine artery |
n | 10 | 10 | 10 | 10 | / | / | / |
KPSS (mN) | 13.22 ± 7.00 | 13.22 ± 7.00 | 13.22 ± 7.00 | 13.22 ± 7.00 | / | / | / |
Contraction /max(%KPSS) | 88.34 ± 21.81 | 82.73 ± 36.21 | 64.52 ± 46.20 | 108.51 ± 21.07 | 0.6237 | 0.256 | 0.031# |
pEC50 | 5.223 ± 0.083 | 4.493 ± 1.35 | 5.084 ± 0.17 | 7.87 ± 0.56 | 0.054 | 0.116 | < 0.001# |
Mesenteric artery |
n | 10 | 10 | 10 | 10 | / | / | / |
KPSS (mN) | 12.11 ± 6.70 | 12.11 ± 6.70 | 12.11 ± 6.70 | 12.11 ± 6.70 | / | / | / |
Contraction /max(%KPSS) | 76 ± 26 | 83 ± 17 | 62 ± 26 | 70 ± 33 | 0.443 | 0.029# | 0.238 |
pEC50 | 5.252 ± 0.06 | 5.617 ± 0.11 | 4.92 ± 0.10 | 7.958 ± 0.38 | < 0.001# | < 0.001# | < 0.001# |
- P value (one-way analysis of variance, Dunnett’s post hoc comparison to norepinephrine). Contraction/max (%KPSS) = maximum response to the vasoactive drugs; KPSS (potassium depolarizing solution) = maximum contractile force of artery to potassium chloride stimulation; n = number of arteries from separate rats; pEC50 = negative logarithm of the concentration of vasopressor agent required to elicit 50% maximum response; P: Phenylephrine; N Norepinephrine; M Metaraminol; V Vasopressin. #P < 0.05 for Group P, Group M and Group V compared to Group N. The results showed that the maximum contraction of vasopressin was significantly higher than norepinephrine for the uterine artery (p = 0.031). The pEC50 comparison revealed that vasopressin was significantly higher than norepinephrine (p < 0.001). The Emax of norepinephrine was significantly higher than metaraminol for the mesenteric artery (p = 0.029). The pEC50 of norepinephrine was significantly higher than phenylephrine and metaraminol (p < 0.001), and vasopressin was significantly higher than norepinephrine (p < 0.001)
