Flow-controlled ventilation (FCV) improves regional ventilation in obese patients – a randomized controlled crossover trial

Table 2 Respiratory and hemodynamic variables

Variable	Baseline	VCV	FCV	p_vent
V_T (mL)	440.2 ± 33.0	442.0 ± 33.2	457.4 ± 50.7	0.148
V_T PBW (ml∙kg^− 1)	7.3 ± 1.0	7.3 ± 1.0	7.4 ± 0.8	0.621
VF (min^− 1)	14.2 ± 2.4	14.1 ± 2.6	14.0 ± 2.5	0.834
P_Plat (cmH₂O)	19.6 ± 3.7	20.2 ± 3.4	20.2 ± 3.8	0.441
P_mean (cmH₂O)	12.9 ± 1.2	13.1 ± 1.1	14.8 ± 2.2*^#	< 0.001
P_{mean expiration} (cmH₂O)	10.6 ± 0.1	10.7 ± 0.1	14.2 ± 1.9*^#	< 0.001
C_RS (ml∙cmH₂O^− 1)	46.6 ± 17.0	47.2 ± 16.6	44.6 ± 16.3	0.272
Heart rate (min^− 1)	60.0 ± 11.8	57.5 ± 10.4	57.7 ± 10.0	0.261
Systolic blood pressure (mmHg)	135.0 ± 15.6	131.0 ± 19.2	131.0 ± 12.6	0.343
Diastolic blood pressure (mmHg)	75.8 ± 12.1	74.4 ± 10.4	71.0 ± 11.4	0.132
MAP (mmHg)	95.5 ± 12.0	93.4 ± 12.8	91.0 ± 10.2	0.167
SpO₂ (%)	99.4 ± 0.96	99.2 ± 1.5	99.1 ± 1.79	0.642
SpO₂/ FiO₂ (%)	1.7 ± 0.02	1.7 ± 0.02	1.7 ± 0.03	0.642

Values are stated as mean ± SD. Baseline, baseline measurements (consisting of volume-controlled ventilation); VCV Volume-controlled ventilation, FCV Flow-controlled ventilation, V_T tidal volume, V_T PBW tidal volume per predicted body weight, VF Ventilation frequency, P_Plat Plateau pressure, P_mean mean tracheal pressure, P_{mean expiration} mean tracheal pressure during expiration, C_RS Respiratory system compliance, MAP Mean arterial pressure, SpO₂ Peripheral oxygen saturation, FiO₂ Fraction of inspired oxygen, p_vent p for ventilation mode* = p < 0.001 for FCV vs. baseline and for ^# = p < 0.001 for FCV vs. VCV. Linear mixed effect model analyses were used to check for differences between the ventilation phases using R based software (jamovi project 2018, version 0.9.2.3). The randomization had no significant effect on the measured respiratory and hemodynamic variables

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