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Table 3 Pharmacokinetic Parameters Derived from the Conventional Two-compartment Model after Administration of Cisatracurium

From: Abnormal cisatracurium pharmacodynamics and pharmacokinetics among patients with severe aortic regurgitation during anesthetic induction

Parameter

Control

AR

K10 (1/min)

0.06 ± 0.01

0.07 ± 0.01

K20 (1/min)

0.04 ± 0.01

0.04 ± 0.01

K12 (1/min)

0.26 ± 0.02

0.19 ± 0.01*

K21 (1/min)

0.19 ± 0.01

0.11 ± 0.01*

V1 (ml/kg)

56.68 ± 7.79

52.34 ± 5.67

V2 (ml/kg)

41.31 ± 6.26

38.90 ± 5.48

T1/2α (min)

1.52 ± 0.12

2.56 ± 0.16*

T1/2β (min)

21.82 ± 3.02

23.76 ± 3.34

CL (ml/min/kg)

6.76 ± 1.36

7.06 ± 1.51

AUC (min*μg/ml)

23.81 ± 5.14

28.79 ± 6.25*

  1. The mean values of PK parameters for both groups were shown here. All data were presented as means±SD. Statistcal differences between the two groups were indicated by asteriks (**P < 0.01). K10, elimination rate constant for central compartment; K20, elimination rate constant for peripheral compartment; K12, transfer rate constant from central compartment to peripheral compartment; K21, transfer rate constant from peripheral compartment to central compartment; V1, volume of the central compartment; V2, volume of the peripheral compartment; T1/2α, distribution half-life; T1/2β, elimination half-life; CL clearance; AUC area under the curve
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BMC Anesthesiology

ISSN: 1471-2253

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