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Table 1 Prevalence of malignant hyperthermia (MH) according to selected characteristics in the 47,178,322 delivery-related discharges of the 2003–2014 National Inpatient Sample

From: Prevalence of malignant hyperthermia diagnosis in obstetric patients in the United States, 2003 to 2014

 Discharges (Nw)Discharges with MH (Nw)Prevalence (per 100,000; 95% CI)P-valueCrude OR (95% CI)Adjusted OR a (95% CI)
Patient characteristic
 Age (year)   0.67  
   ≤ 194,399,524180.41 (0.24–0.65) 0.96 (0.58–1.58)1.02 (0.62–1.67)
  20–2924,436,4871060.43 (0.36–0.52) ReferenceReference
  30–3917,029,672860.51 (0.40–0.62) 1.17 (0.88–1.56)1.15 (0.86–1.54)
   ≥ 401,310,043--b--b (0.12–0.89) --b (0.33–2.11)0.85 (0.33–2.16)
 Race   0.006  
  White, Non-Hispanic20,333,2431020.50 (0.41–0.61) ReferenceReference
  Black5,268,451240.46 (0.29–0.68) 0.90 (0.58–1.40)0.82 (0.52–1.29)
  Hispanic9,035,771200.22 (0.14–0.34) 0.44 (0.27–0.71)0.47 (0.29–0.76)
  Other4,166,949150.36 (0.20–0.59) 0.70 (0.40–1.20)0.78 (0.45–1.35)
 Charlson comorbidity index   0.85  
  047,035,7922150.46 (0.40–0.52) 
   ≥ 1142,53000.00 (0.00–2.59) 
Patient
 Comorbidity index for obstetric patients   0.92  
  0 or 141,467,9321880.45 (0.39–0.52) ReferenceReference
   ≥ 25,707,789270.47 (0.31–0.69) 1.06 (0.71–1.58)0.79 (0.52–1.19)
Hospital
 Location and teaching status   0.023  
  Rural5,270,124370.70 (0.49–0.97) 1.63 (1.12–2.39)1.34 (0.91–1.98)
  Urban non-teaching19,230,712830.43 (0.34–0.54) 1.01 (0.75–1.36)0.96 (0.71–1.30)
  Urban teaching22,458,351960.43 (0.35–0.52) ReferenceReference
Hospital
 Census region   <  0.001  
  Northeast7,678,323200.26 (0.16–0.40) ReferenceReference
  Midwest10,088,837510.51 (0.38–0.66) 1.96 (1.17–3.29)1.71 (0.99–2.93)
  South17,827,2281140.64 (0.53–0.77) 2.47 (1.54–3.98)2.44 (1.50–3.96)
  West11,583,934290.25 (0.17–0.36) 0.98 (0.55–1.73)1.11 (0.62–1.98)
Time period   0.17  
Year
 2003–200616,163,993860.53 (0.43–0.66) ReferenceReference
 2007–201016,049,577690.43 (0.33–0.54) 0.81 (0.59–1.11)0.81 (0.59–1.12)
 2011–201414,964,752590.39 (0.30–0.51) 0.75 (0.54–1.04)0.77 (0.55–1.09)
  1. Abbreviation: CI confidence interval, Nw weighted number, OR odds ratio
  2. a Adjustment used all the variables listed in this table, along with the mode of delivery (vaginal or cesarean)
  3. b Because of HCUP data use agreement restrictions on small cell size, the number of observed cases and exact proportions are not presented