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Table 1 Prevalence of malignant hyperthermia (MH) according to selected characteristics in the 47,178,322 delivery-related discharges of the 2003–2014 National Inpatient Sample

From: Prevalence of malignant hyperthermia diagnosis in obstetric patients in the United States, 2003 to 2014

 

Discharges (Nw)

Discharges with MH (Nw)

Prevalence (per 100,000; 95% CI)

P-value

Crude OR (95% CI)

Adjusted OR a (95% CI)

Patient characteristic

 Age (year)

   

0.67

  

   ≤ 19

4,399,524

18

0.41 (0.24–0.65)

 

0.96 (0.58–1.58)

1.02 (0.62–1.67)

  20–29

24,436,487

106

0.43 (0.36–0.52)

 

Reference

Reference

  30–39

17,029,672

86

0.51 (0.40–0.62)

 

1.17 (0.88–1.56)

1.15 (0.86–1.54)

   ≥ 40

1,310,043

--b

--b (0.12–0.89)

 

--b (0.33–2.11)

0.85 (0.33–2.16)

 Race

   

0.006

  

  White, Non-Hispanic

20,333,243

102

0.50 (0.41–0.61)

 

Reference

Reference

  Black

5,268,451

24

0.46 (0.29–0.68)

 

0.90 (0.58–1.40)

0.82 (0.52–1.29)

  Hispanic

9,035,771

20

0.22 (0.14–0.34)

 

0.44 (0.27–0.71)

0.47 (0.29–0.76)

  Other

4,166,949

15

0.36 (0.20–0.59)

 

0.70 (0.40–1.20)

0.78 (0.45–1.35)

 Charlson comorbidity index

   

0.85

  

  0

47,035,792

215

0.46 (0.40–0.52)

 

   ≥ 1

142,530

0

0.00 (0.00–2.59)

 

Patient

 Comorbidity index for obstetric patients

   

0.92

  

  0 or 1

41,467,932

188

0.45 (0.39–0.52)

 

Reference

Reference

   ≥ 2

5,707,789

27

0.47 (0.31–0.69)

 

1.06 (0.71–1.58)

0.79 (0.52–1.19)

Hospital

 Location and teaching status

   

0.023

  

  Rural

5,270,124

37

0.70 (0.49–0.97)

 

1.63 (1.12–2.39)

1.34 (0.91–1.98)

  Urban non-teaching

19,230,712

83

0.43 (0.34–0.54)

 

1.01 (0.75–1.36)

0.96 (0.71–1.30)

  Urban teaching

22,458,351

96

0.43 (0.35–0.52)

 

Reference

Reference

Hospital

 Census region

   

<  0.001

  

  Northeast

7,678,323

20

0.26 (0.16–0.40)

 

Reference

Reference

  Midwest

10,088,837

51

0.51 (0.38–0.66)

 

1.96 (1.17–3.29)

1.71 (0.99–2.93)

  South

17,827,228

114

0.64 (0.53–0.77)

 

2.47 (1.54–3.98)

2.44 (1.50–3.96)

  West

11,583,934

29

0.25 (0.17–0.36)

 

0.98 (0.55–1.73)

1.11 (0.62–1.98)

Time period

   

0.17

  

Year

 2003–2006

16,163,993

86

0.53 (0.43–0.66)

 

Reference

Reference

 2007–2010

16,049,577

69

0.43 (0.33–0.54)

 

0.81 (0.59–1.11)

0.81 (0.59–1.12)

 2011–2014

14,964,752

59

0.39 (0.30–0.51)

 

0.75 (0.54–1.04)

0.77 (0.55–1.09)

  1. Abbreviation: CI confidence interval, Nw weighted number, OR odds ratio
  2. a Adjustment used all the variables listed in this table, along with the mode of delivery (vaginal or cesarean)
  3. b Because of HCUP data use agreement restrictions on small cell size, the number of observed cases and exact proportions are not presented