Table 3 Hematologic, coagulation standard and TEG parameters, and clinical bleeding as assessed by surgeon at baseline (T1), after bypass and administration of protamine (T2), at sternal closure (T3), and in ICU after 12 h (T4). Data are presented as median (range)

Hb (g dl⁻¹)

13.4 (8.2–18.4)

11.4 (8.5–15.8)

12.2 (9.3–16.9)

13.7 (9.5–17.8)

<  0.001

1.4 to 3.1

ns

Hct (%)

40.6 (25.2–55.1)

34.9 (24.1–48.5)

36.7 (28.5–49.0)

38.1 (26.9–52.5)

<  0.001

− 23.7 to 0.51

ns

PLT (10⁹ L⁻¹)

279 (155–621)

116 (68–266)

219 (112–329)

246 (123–380)

<  0.001

− 233 to − 169.5

<  0.001

83.9 to 121.

Quick (%)

92 (54–129)

49 (40–82)

85 (62–130)

83 (59–130)

<  0.001

− 44.1 to −33.8

<  0.001

28.6 to 37.9

aPTT (s)

32 (23–50)

41 (31–55)

38 (26–59)

31 (24–49)

ns

ns

ACT (s)

110 (91–148)

114 (91–146)

106 (79–138)

110 (89–126)

ns

ns

Fib (g L⁻¹)

1.7 (0.9–3.3)

1.4 (0.3–2.2)

2.2 (1.5–3.5)

2.5 (1.3–3.8)

<  0.001

−0.49 to − 0.14

<  0.001

0.6 to 1.0

AT III (%)

89 (44–120)

67 (47–97)

67 (47–91)

76 (46–101)

<  0.001

−28.1 to − 14.3

ns

F II (%)

60 (32–94)

49 (34–87)

113 (70–170)

101 (62–167)

0.04

−12.5 to − 1.5

<  0.001

56.3 to 72.2

F V (%)

77 (57–121)

61 (37–81)

60 (32–89)

72 (33–148)

ns

ns

R (min)

6.9 (4.3–10.7)

10.0 (5.7–15.3)

7.9 (5.2–12.1)

7.2 (3.5–11.2)

<  0.001

1.9 to 3.1

<  0.001

−2.2 to −0.6

K (min)

1.5 (0.9–4.3)

2.8 (0.9–7.4)

1.8 (1.0–3.7)

1.2 (0.7–2.1)

<  0.001

0.7 to 1.5

<  0.001

−1.4 to −0.6

Angle (degree)

70.7 (48.4–77.8)

59.1 (38.0–77.4)

68.9 (56.9–77.8)

74.4 (63.9–81.7)

< 0.001

− 11.7 to −5.9

<  0.001

5.9 to 11.3

MA (mm)

59.0 (43.9–69.7)

48.9 (30.5–64.1)

62.0 (50.6–68.6)

64.3 (55–69.6)

< 0.001

−12.0 to – 7.3

< 0.001

9.1 to 13.5

MA-fib (mm)

19.6 (11.1–35.5)

13.2 (4.9–21.0)

29.1 (19.5–53.2)

32.0 (23.0–50.6)

<  0.001

−9.5 to −6.1

<  0.001

15.5 to 19.9

LY30 (%)

0.6 (0–5.1)

0.0 (0–3.2)

0.0 (0–3.8)

0.6 (0–2.7)

0.008

−1.1 to 0.2

ns

Bleeding (NRS 0–10)

6 (2–10)

2 (0–4)

<  0.001

−4.8 to −3.6