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Table 3 Hematologic, coagulation standard and TEG parameters, and clinical bleeding as assessed by surgeon at baseline (T1), after bypass and administration of protamine (T2), at sternal closure (T3), and in ICU after 12 h (T4). Data are presented as median (range)

From: Prevention of postoperative bleeding after complex pediatric cardiac surgery by early administration of fibrinogen, prothrombin complex and platelets: a prospective observational study

  T1 T2 T3 T4 P (T1 vs T2) 95%-CI for P (T1 vs T2) P (T2 vs T3) 95%-CI for P (T2 vs T3)
Hb (g dl−1) 13.4 (8.2–18.4) 11.4 (8.5–15.8) 12.2 (9.3–16.9) 13.7 (9.5–17.8) <  0.001 1.4 to 3.1 ns  
Hct (%) 40.6 (25.2–55.1) 34.9 (24.1–48.5) 36.7 (28.5–49.0) 38.1 (26.9–52.5) <  0.001 − 23.7 to 0.51 ns  
PLT (109 L−1) 279 (155–621) 116 (68–266) 219 (112–329) 246 (123–380) <  0.001 − 233 to − 169.5 <  0.001 83.9 to 121.
Quick (%) 92 (54–129) 49 (40–82) 85 (62–130) 83 (59–130) <  0.001 − 44.1 to −33.8 <  0.001 28.6 to 37.9
aPTT (s) 32 (23–50) 41 (31–55) 38 (26–59) 31 (24–49) ns   ns  
ACT (s) 110 (91–148) 114 (91–146) 106 (79–138) 110 (89–126) ns   ns  
Fib (g L−1) 1.7 (0.9–3.3) 1.4 (0.3–2.2) 2.2 (1.5–3.5) 2.5 (1.3–3.8) <  0.001 −0.49 to − 0.14 <  0.001 0.6 to 1.0
AT III (%) 89 (44–120) 67 (47–97) 67 (47–91) 76 (46–101) <  0.001 −28.1 to − 14.3 ns  
F II (%) 60 (32–94) 49 (34–87) 113 (70–170) 101 (62–167) 0.04 −12.5 to − 1.5 <  0.001 56.3 to 72.2
F V (%) 77 (57–121) 61 (37–81) 60 (32–89) 72 (33–148) ns   ns  
R (min) 6.9 (4.3–10.7) 10.0 (5.7–15.3) 7.9 (5.2–12.1) 7.2 (3.5–11.2) <  0.001 1.9 to 3.1 <  0.001 −2.2 to −0.6
K (min) 1.5 (0.9–4.3) 2.8 (0.9–7.4) 1.8 (1.0–3.7) 1.2 (0.7–2.1) <  0.001 0.7 to 1.5 <  0.001 −1.4 to −0.6
Angle (degree) 70.7 (48.4–77.8) 59.1 (38.0–77.4) 68.9 (56.9–77.8) 74.4 (63.9–81.7) < 0.001 − 11.7 to −5.9 <  0.001 5.9 to 11.3
MA (mm) 59.0 (43.9–69.7) 48.9 (30.5–64.1) 62.0 (50.6–68.6) 64.3 (55–69.6) < 0.001 −12.0 to – 7.3 < 0.001 9.1 to 13.5
MA-fib (mm) 19.6 (11.1–35.5) 13.2 (4.9–21.0) 29.1 (19.5–53.2) 32.0 (23.0–50.6) <  0.001 −9.5 to −6.1 <  0.001 15.5 to 19.9
LY30 (%) 0.6 (0–5.1) 0.0 (0–3.2) 0.0 (0–3.8) 0.6 (0–2.7) 0.008 −1.1 to 0.2 ns  
Bleeding (NRS 0–10)   6 (2–10) 2 (0–4)     <  0.001 −4.8 to −3.6
  1. Abbreviations: ns not significant, Hb haemoglobin, Hct haematocrit, PLT platelets, Quick Quick value of prothrombin time, aPTT activated partial thromboplastin time, ACT activated clotting time, Fib fibrinogen, AT III Antithrombin, F II factor II, F V factor V, R reaction time, K kinetic time, MA maximum amplitude, MA-fib maximum amplitude of functional fibrinogen, LY30 fibrinolysis at 30 min