Fig. 2

Dexmedetomidine attenuated release of pro-inflammatory factors after brain I/R. After reperfusion for 72 h, ischemic brain tissue was harvested to assess the release of IL-1β (a), IL-6 (b), TNF-α (c) through ELISA kits. Results of B-D were presented with mean ± SD (n = 10) and analyzed using One-way ANOVA followed by Tukey’s multiple comparisons test. **P < 0.001 between MCAO+DEX and MCAO+NS or between MCAO+DEX + YOH and MCAO+DEX. NS, normal saline. DEX, dexmedetomidine. YOH, yohimbine. TTC, 2,3,5-triphenyl-tetrazolium chloride