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Table 4 Effect of baseline parameters on the time evolution of IL-6 and HMGB1 levels

From: Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study

Variable

Coefficient (SE) on IL-6*

P-value

Coefficient (SE)

on HMGB1*

P-value

Age (years)

0.13 (0.041)

0.0044

0.026 (0.033)

0.45

Gender (Male vs. Female)

0.75 (0.54)

0.18

0.30 (0.41)

0.47

BMI (kg/m2)

0.027 (0.049)

0.59

−0.060 (0.033)

0.079

Education level(a)

−0.27 (0.29)

0.35

−0.37 (0.21)

0.086

No. of languages known

−0.027 (0.25)

0.95

0.24 (0.19)

0.21

Working (Yes vs. No)

−0.79 (0.63)

0.23

0.15 (0.50)

0.77

Marital status

 (Divorced vs Married)

0.19 (0.63)

0.77

−0.25 (0.48)

0.60

 (Widow vs. Married)

−0.85 (0.95)

0.38

−0.45 (0.64)

0.49

Self-sufficient (Yes vs. No)

−0.53 (1.10)

0.63

−0.22 (0.73)

0.77

Living situation (No. of people)

0.038 (0.42)

0.93

0.33 (0.31)

0.29

No. of alcoholic drinks/week(b)

−0.078 (0.22)

0.72

−0.024 (0.17)

0.89

Smoking Status

 (Current vs. Never)

−0.45 (0.63)

0.48

0.55 (0.45)

0.23

 (Past vs. Never)

−0.73 (0.71)

0.31

0.79 (0.53)

0.15

Surgery

 (Orthopedic vs. General)

0.19 (0.67)

0.78

−0.39 (0.49)

0.44

 (Genitourinary vs. General)

−0.80 (0.66)

0.23

−0.90 (0.48)

0.073

No. of psychoactive medications(b)

−1.25 (0.59)

0.041

−0.40 (0.47)

0.40

Type 2 Diabetes (Yes vs. No)

0.79 (0.64)

0.22

0.53 (0.45)

0.25

IPAQ work-related (h/week)(b)

−1.55 (0.65)

0.024

0.064 (0.55)

0.91

IPAQ transport-related (h/day)(b)

−0.36 (0.63)

0.57

−0.41 (0.44)

0.36

IPAQ household-related (h/day)(b)

−0.30 (0.53)

0.57

−0.65 (0.38)

0.092

IPAQ leisure time-related (h/day)(b)

−0.86 (0.66)

0.21

−0.093 (0.51)

0.86

IPAQ sitting time (h/day)(b)

0.058 (0.62)

0.93

−0.40 (0.43)

0.36

Energy (METs-min)(b)

−0.012 (0.032)

0.71

0.0030 (0.023)

0.90

GDS

0.039 (0.062)

0.54

−0.009 (0.045)

0.84

MMSE baseline

0.029 (0.074)

0.70

0.038 (0.051)

0.46

IL-6 baseline (pg/ml)(c)

0.86 (0.084)

< 0.0001

0.059 (0.14)

0.69

HMGB1 baseline (pg/ml)(c)

0.097 (0.18)

0.59

0.68 (0.065)

< 0.0001

  1. *covariate regression coefficients are adjusted for time; a positive (negative) coefficient is associated with an increasing (lowering) impact of parameter on IL-6 or HMBD1 levels over time
  2. (a) treated as an ordinal variable
  3. (b) square root transform applied to normalize the distribution
  4. (c) log-transform applied to normalize the distribution
  5. BMI Body mass index, SE Standard error, MMSE Mini-mental state examination, IPAQ International Physical Activity questionnaire, IL Interleukin, HMGB1 High molecular group box protein 1, METs Metabolic equivalents, GDS Geriatric depression scale
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BMC Anesthesiology

ISSN: 1471-2253

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