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Table 2 pH and percentage of the original remifentanil/propofol remaining over 24 h when mixed

From: The effect of concentration, reconstitution solution and pH on the stability of a remifentanil hydrochloride and propofol admixture for simultaneous co-infusion

 

10 μg mL− 1

20 μg mL− 1

30 μg mL− 1

40 μg mL− 1

50 μg mL− 1

1 h

6 h

12 h

24 h

1 h

6 h

12 h

24 h

1 h

6 h

12 h

24 h

1 h

6 h

12 h

24 h

1 h

6 h

12 h

24 h

Percent Remifentanil Remaining in Remifentanil-Propofol Mixture (mean ± SEM; n = 3)

 W

99.5 ± 2.40

81.5 ± 1.58

64.7 ± 2.49

43.3 ± 2.02

100.3 ± 3.47

84.4 ± 4.41

67.0 ± 2.34

46.7 ± 2.82

97.9 ± 0.72

83.1 ± 2.94

67.4 ± 3.42

48.2 ± 5.09

97.3 ± 0.63

81.7 ± 1.43

^

66.0 ± 2.56

^

45.3 ± 2.89

^

97.7 ± 0.18

83.1 ± 0.53

^

67.0 ± 0.73

46.9 ± 1.22

 0.9%

93.5 ± 0.61

70.5 ± 1.24

*

53.8 ± 1.15

*

35.0 ± 0.49

* d

96.7 ± 0.95

74.1 ± 1.11

d

58.6 ± 1.29

* a, d

35.9 ± 1.91

* d

96.0 ± 0.49

78.0 ± 0.85

a, b

61.2 ± 1.36

a

37.4 ± 1.34

d

94.4 ± 0.74

*

74.9 ± 0.98

* a, d

56.7 ± 1.19

* d

34.8 ± 1.56

* d

95.6 ± 0.83

79.7 ± 1.01

* a

65.6 ± 1.26

a

46.2 ± 1.08

 20%

96.6 ± 2.02

80.8 ± 2.08

63.3 ± 1.13

45.2 ± 2.30

96.0 ± 0.43

79.6 ± 0.86

66.3 ± 0.51

48.9 ± 1.93

96.6 ± 1.10

83.9 ± 0.84

b

71.4 ± 0.24

# a, b

53.5 ± 0.58

# a

97.5 ± 0.36

86.0 ± 0.34

b

75.0 ± 1.01

a, b, c

56.7 ± 0.37

a, b, c

98.8 ± 0.22

*

86.8 ± 0.67

b

74.8 ± 0.80

* a, b, c

60.0 ± 1.41

* a, b, c

Percent Propofol Remaining in Remifentanil-Propofol Mixture (mean ± SEM; n = 3)

 W

99.6 ± 0.21

c

99.2 ± 0.21

d

98.7 ± 0.20

b

97.9 ± 0.21

c

99.5 ± 0.16

c

100.0 ± 0.21

d

99.4 ± 0.10

^ d

98.3 ± 0.38

c

100.6 ± 0.00

^

99.7 ± 0.65

99.4 ± 0.32

d

99.5 ± 0.17

^

99.6 ± 0.19

c

99.3 ± 0.40

99.0 ± 0.12

d

97.8 ± 0.02

c

100.1 ± 0.16

c

98.0 ± 0.28

#

96.9 ± 0.67

#

97.9 ± 0.17

c

 0.9%

100.8 ± 0.62

99.2 ± 0.58

98.6 ± 0.09

96.8 ± 0.97

98.0 ± 0.86

99.9 ± 0.53

98.0 ± 0.65

97.2 ± 0.59

98.6 ± 0.84

100.5 ± 1.80

100.5 ± 1.46

99.1 ± 1.58

100.1 ± 0.26

99.7 ± 0.15

98.3 ± 0.33

97.7 ± 0.06

99.6 ± 0.24

99.6 ± 0.11

99.3 ± 0.49

98.7 ± 0.49

 20%

99.8 ± 0.13

99.4 ± 0.62

98.6 ± 0.42

99.3 ± 0.49

99.0 ± 0.27

98.4 ± 0.74

97.7 ± 0.49

97.3 ± 0.79

99.5 ± 0.28

98.1 ± 0.89

97.9 ± 0.84

96.5 ± 0.64

a

99.5 ± 0.24

99.4 ± 0.22

98.4 ± 0.35

97.2 ± 0.25

a

99.2 ± 0.32

98.9 ± 0.31

98.5 ± 0.46

96.5 ± 0.86

a

pH of Solution (mean ± SEM; n = 6)

 W

7.42 ± 0.12

7.41 ± 0.10

7.42 ± 0.12

^

6.72 ± 0.40

7.19 ± 0.14

d

7.18 ± 0.11

7.12 ± 0.13

6.66 ± 0.33

7.02 ± 0.16

6.98 ± 0.13

a

6.95 ± 0.16

a

6.55 ± 0.36

6.88 ± 0.20

a

6.89 ± 0.18

a

6.87 ± 0.18

a

6.31 ± 0.43

6.59 ± 0.23

a

6.67 ± 0.20

a

6.67 ± 0.23

a

6.20 ± 0.41

 0.9%

7.17 ± 0.04

7.17 ± 0.05

7.13 ± 0.09

6.63 ± 0.33

7.10 ± 0.08

7.05 ± 0.06

6.94 ± 0.06

6.64 ± 0.26

6.87 ± 0.08

a

6.89 ± 0.07

a

6.75 ± 0.06

a

6.48 ± 0.28

6.68 ± 0.10

a, b

6.74 ± 0.09

a, b

6.66 ± 0.10

a, b

6.12 ± 0.35

6.44 ± 0.16

a, b, c

6.49 ± 0.14

a, b, c

6.47 ± 0.15

a, b

6.13 ± 0.33

 20%

7.01 ± 0.01

*

7.00 ± 0.01

*

6.94 ± 0.03

6.36 ± 0.31

6.79 ± 0.02

* a

6.79 ± 0.02

* a

6.69 ± 0.08

*, a

5.95 ± 0.39

6.64 ± 0.02

* a, b

6.66 ± 0.01

* a, b

6.62 ± 0.03

a

5.84 ± 0.38

6.51 ± 0.05

e

6.53 ± 0.04

e

6.48 ± 0.06

a

5.72 ± 0.41

6.30 ± 0.06

a, b, c

6.34 ± 0.06

a, b, c

6.33 ± 0.08

a, b, c

5.71 ± 0.36

  1. W = water, 0.9% = 0.9% saline, 20% = 20% saline
  2. *P < 0.05 vs. all other reconstitution solutions; #P < 0.05 vs. 0.9% saline solution; ^P < 0.05 vs. 20% saline solution
  3. aP < 0.05 vs. 10 μg mL− 1; bP < 0.05 vs. 20 μg mL− 1; cP < 0.05 vs. 30 μg mL− 1; dP < 0.05 vs. 50 μg mL− 1; eP < 0.05 vs. all other concentrations
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BMC Anesthesiology

ISSN: 1471-2253

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