Table 1 Characteristics of the included studies
Author/ year | Country | Surgery type | Anesthesia type | Age | MAP during surgery (mm Hg) | Duration of intervention (min) | Low-target | High-target | Cognitive assessment | Outcome | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low-target | High-target | Low-target | High-target | Events | Total | Events | Total | Method | Time (after surgery) | ||||||
Gold 1995 [20] | USA | CPB | General anesthesia | No reported | 50–60 | 80–100 | 89.4 ± 31.5 | 84.9 ± 28.3 | 13 | 113 | 12 | 112 | Neuropsychologic battery | 6 months | POCD |
Langer 2019 [21] | Italy | Non-cardiac surgery | General anesthesia | ≥75 | No-Target | ≥90% of baseline | 193 ± 117 | 198 ± 108 | 3 | 41 | 4 | 36 | MMSE scores | 3 months | POCD |
| Â | Â | Â | Â | Â | Â | Â | Â | Â | 7 | 51 | 3 | 50 | CAM-ICU scale | Once daily | POD |
Siepe 2011 [9] | Germany | CPB | General anesthesia | ≥55 | 60–70 | 80–90 | 101 ± 25 | 91 ± 30 | 6 | 48 | 0 | 44 | MMSE scores | 48 h | POD |
Vedel 2018 [22] | Denmark | CPB | General anesthesia | ≥18 | 40–50 | 70–80 | 94 ± 33 | 105.6 ± 77.4 | 8 | 89 | 5 | 75 | ISPOCD battery | 3 months | POCD |
Williams 1999 [23] | USA | Total hip replacement | Epidural anesthesia | ≥50 | 45–55 | 55–70 | No reported | No reported | 10 | 117 | 4 | 118 | Neuropsychologic battery | 4 months | POCD |