Table 3 Population kinetic parameters in the final model
From: Volume kinetic analysis of fluid retention after induction of general anesthesia
Covariate | Best estimate | 2.5% CI | 97.5% CI | CV% | |
|---|---|---|---|---|---|
Fixed parameter | |||||
tvVc (mL) | – | 3205 | 2906 | 3504 | 4.8 |
tvk12 (10− 3 min− 1) | – | 69.0 | 46.3 | 91.7 | 16.7 |
tvk21 (10− 3 min−1) | – | 93.5 | 67.8 | 119.5 | 14.1 |
tvk10 (10− 3 min−1) | – | 0.86 | 0.72 | 1.00 | 8.4 |
tvkb (10− 3 min−1) | – | 15.8 | 12.0 | 19.6 | 12.1 |
Covariate effect | |||||
k12 | Time ≤ 20 min | −16.5 | − 19.0 | −14.0 | −7.8 |
kb | Time ≤ 20 min | − 16.5 | −7.9 | −19.0 | − 7.9 |
Vc | Time ≤ 20 min | −0.35 | − 0.44 | − 0.26 | − 13.3 |
Vc | Body weight | 1.49 | 0.96 | 2.03 | 18.2 |
k10 | BNP | 0.37 | 0.12 | 0.62 | 33.9 |
k21 | MAP | −1.47 | −1.99 | −0.94 | − 18.1 |