Fig. 2
Haemodynamic value fluctuation, train-of-four, Paw pressure and bispectral index value changes in three groups. Data are presented as mean ± SD. * statistical significance between the 50 μg·kg− 1 group vs. 30 μg·kg−1 group, P < 0.05; ‡statistically significant difference between the 50 μg·kg− 1 and 20 μg·kg− 1 groups, P < 0.05; # statistically significant difference between the 30 μg·kg− 1 and 20 μg·kg− 1 groups, P < 0.05. There were ten timepoints: T1: administration of cis-atracurium, T2: 3 min after administration of cis-atracurium (LMA insertion), T3: 10 min after administration of cis-atracurium (i.e., beginning of the operation), T4: 20 min after administration of cis-atracurium, T5: 30 min after administration of cis-atracurium, T6: 40 min after administration of cis-atracurium, T7: 50 min after administration of cis-atracurium, T8: 60 min after administration of cis-atracurium, T9: 70 min after administration of cis-atracurium, and T10: 80 min after administration of cis-atracurium. Diastolic blood pressure (DBP) did not significantly differ among the groups. Systolic blood pressure (SBP) was significantly decreased in the 50 μg·kg− 1 group compared to that in the 20 μg·kg− 1 group at T2, T3, and T4 (P = 0.0159, P = 0.0233, and P = 0.0428, respectively). The heart rate (HR) significantly differed among the groups. The HR was significantly decreased in the 50 μg·kg− 1 group compared to that in the 20 μg·kg− 1 group at T7, T8, and T10 (P = 0.0482, P = 0.0460, and P = 0.0236, respectively). The train-of-four [TOF] onset, the time to TOF ratio = 0 TOF value). The TOF value at T3 was significantly lower in the 50 μg·kg− 1 group than in the 30 μg·kg− 1 group (P = 0.0326). The Paw pressure at each timepoint did not significantly differ between the 50 μg·kg− 1 and 30 μg·kg− 1 groups. However, the Paw pressure was significantly higher at T8 in the 30 μg·kg− 1 group than in the 20 μg·kg− 1 group (P = 0.0423)