Table 2 Route of Administration, Doses, Titration Method, and Total Medication Administered of Included Studies
From: Perioperative Dexmedetomidine for outpatient cataract surgery: a systematic review
Study | Routea | Dexmedetomidine Bolus Dose(s)b | Bolus Duration (mins)c | Dexmedetomidine Infusion Rated | Other Treatment Group(s) | Medication Titration | Total Medication Administerede | ||
|---|---|---|---|---|---|---|---|---|---|
Abdalla [23] | IV | 0.5 mcg•kg− 1•hr.− 1 | 10 | 0.2 mcg•kg− 1•hr.− 1 over 50 mins | saline | NA | Unknown | ||
Alhashemi [12] | IV | 1 mcg/kg | 10 | 0.1–0.7 mcg•kg− 1•hr.− 1 | midazolam 20 mcg/kg then 0.5 mg PRNf | RSSg 3 | dexmedetomidine 79.5 (21.7) mcg | ||
midazolam 1.5 (0.6) mg | |||||||||
Altiparmak [24] | IV | – | NA | 0.4 mcg•kg− 1•hr.− 1 | remifentanil 0.05 mcg•kg− 1•min− 1 | Unknown | Unknown | ||
Apan [11] | IV | – | NA | 0.25 mcg•kg− 1•hr.− 1 | midazolam 25 mcg•kg− 1•hr.− 1 or saline | BISh > 85 | dexmedetomidine 18.8 (11.6) mcg | ||
midazolam 1.8 (0.6) mg | |||||||||
Ayoglu [21] | IV | 1 mcg/kg | 10 | patient-controlled sedation (5 mcg bolus dose; 10 min lockout) | no sedation | Patient-controlled sedation | dexmedetomidine 66.4 (3.7) mcg | ||
Dogan [13] | IV | 0.6 mcg/kg | 10 | 0.1–0.5 mcg•kg− 1•hr.− 1 (and topical analgesia or peribulbar block) | fentanyl 0.5 mcg/kg; and midazolam 20 mcg/kg then 5–15 mcg•kg− 1•hr.− 1 (and topical analgesia or peribulbar block) | RSS 3 | Dexmedetomidine infusion | topical analgesia | 8.54 mcg |
peribulbar block | 8.92 mcg | ||||||||
midazolam | topical analgesia | 213.80 mcg | |||||||
peribulbar block | 226.24 mcg | ||||||||
Erdurmus [14] | IV | 1 mcg/kg | 10 | 0.1–0.7 mcg/kg | saline | RSS 3 | Unknown | ||
Ghodki [15] | IV | 1 mcg/kg | 10 | – | saline | RSS 3 | dexmedetomidine 65.4 (3.6) mcg | ||
Kermany [10] | IV | 0.5 mcg/kg | 10 | 0.2 mcg•kg−1•hr.−1 | remifentanil 0.1 mcg/kg over 5 mins then 0.05 mcg•kg− 1•min− 1 | BIS 70–80 | Unknown | ||
Muttu [16] | IV | 1 mcg/kg | 20 | 0.05–0.7 mcg•kg− 1•hr.− 1 | midazolam 50 mcg/kg then 2.5–35.0 mcg•kg− 1•hr.− 1 | RSS 2 | Unknown | ||
Na [17] | IV | – | NA | 0.6 mcg•kg− 1•hr.− 1 | propofol 2 mg•kg− 1•hr.− 1and alfentanil 20 mcg•kg− 1•hr.− 1 | RSS 3 | Unknown | ||
Park [22] | IV | 0.5 mcg/kg | 10 | 0.2 mcg•kg−1•hr.− 1 | Remifentanil target effect site concentration 1 ng/ml | – | Unknown | ||
Virkilla [19] | IM | 0.25 mcg/kg | NA | NA | placebo | 45 mins before regional block | Unknown | ||
0.5 mcg/kg | |||||||||
0.75 mcg/kg | |||||||||
1.0 mcg/kg | |||||||||
1.5 mcg/kg | |||||||||
Virkilla [20] | IM | 1.0 mcg/kg | NA | NA | midazolam 20 mcg/kg and placebo | 45 mins before regional block | Unknown | ||
Yagan [18] | IV | 0.5 mcg/kg | 10 | – | ketofol (200 mg propofol and 100 mg ketamine) 0.125 ml/kg | RSS 3 | Unknown | ||