Fig. 4
From: Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes
Representative Ca2+ transient traces from isolated murine cardiomyocyte under the effect of NCX blockers and in combination with mepivacaine. (a) Response of Ca2+ transient under 1 mM NiCl2 (green) did not significantly altered both baseline (solid black line) neither peak area parameters. Gray arrows indicate electrical stimulation. The combination of 50 μM mepivacaine with 1 mM NiCl2 (brown) induced arrhythmic activity and significant increase in the baseline (p < 0.01; dashed black line). n = 27 cells for control, 31 cells for NiCl2 1 mM and 10 cells for Mepivacaine 50 μM + NiCl2 1 mM. (b) Response of Ca2+ transient under 10 μM ORM-10103 (blue) did not significantly altered both baseline (solid black line) neither peak area parameters. The combination of 50 μM mepivacaine with 10 μM ORM-10103 (purple) induced arrhythmic activity and significant increase in the baseline (p < 0.05; dashed black line). n = 27 cells for control, 24 cells for ORM-10103 10 μM and 10 cells for mepivacaine 50 μM + ORM-10103 10 μM