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Table 2 Intraoperative glucose management protocol for strict glycemic control

From: Intraoperative glycemic control in patients undergoing Orthotopic liver transplant: a single center prospective randomized study

Insulin Infusion Protocol

Column 1†

Column 2‡

Column 3§

Serum Glucose Level, mg/dL

Insulin Infusion Rate, U/h

Serum Glucose Level, m/dL

Insulin Infusion Rate, U/h

Serum Glucose Level, mg/dL

Insulin Infusion Rate, U/h

> 400

18

> 400

25

> 400

30

351–400

16

351–400

22

351–400

27

301–350

14

301–350

20

301–350

24

251–300

12

251–300

18

251–300

21

201–250

10

201–250

15

201–250

18

176–200

8

176–200

12

176–200

15

151–175

6

151–175

9

151–175

12

121–150

4

121–150

7

121–150

9

101–120

2

101–120

4

101–120

6

80–100

1

80–100

2

80–100

3

< 80

Off

< 80

Off

< 80

Off

  1. 1When glucose level is < 80 mg/dL, stop insulin infusion and initiate 50 mL/h of 10% dextrose infusion. Check glucose every 30 min until glucose level is ≥80 mg/dL - Discontinue 10% dextrose infusion. Resume insulin infusion, always in column 1. If glucose level is < 70 mg/dL, initiate treatment of hypoglycemia protocol. Restart insulin infusion in column 1 when glucose level ≥ 80 mg/dL
  2. † Start in this column; restart in this column when insulin infusion has to be discontinued for glucose level < 80 mg/dL
  3. ‡ Patient has not reached glucose level range of 80–110 mg/dL within 2 h of using column 1 and glucose level has decreased by < 50 mg/dL over preceding 1 h
  4. § Patient had not reached glucose level range of 80–110 mg/dL within 2 h of using column 2 and glucose level has decreased by < 50 mg/dL over preceding 1 h
  5. Target: 80–120 mg/dL
  6. Trigger: One blood glucose > 130 or two blood glucoses > 120 when checked 30 min apart. Bolus doses should not be necessary using this protocol
  7. Hypoglycemia protocol (If blood glucose < 70 mg/dL): Hold infusion, give 25 ml of 50% dextrose IV bolus (1/2 vial) and start 50mls/hr. 10% glucose. Re-check BG every 15 min until BG > 70 mg/dL, then every 30 min