From: Neutrophil extracellular trap formation and nuclease activity in septic patients
Variable | Healthy volunteers (n = 27) | Patients with sepsis (n = 18) | p-value |
---|---|---|---|
Mean age, years | 33 ± 14 | 49 ± 17 | < 0.0001 |
Females / males, N (%) | 20 (74) / 7 (26) | 2 (11) / 16 (89) | < 0.0001 |
Leukocyte blood concentration (103 μl− 1) | 6 ± 1 | 18 ± 15 | 0.002 |
Neutrophil blood concentration (103 μl-1) | 3 ± 0.5 | 17 ± 7 | ≤0.0001 |
Immature neutrophils (% of all neutrophils) | n/a | 10 ± 12 | |
C-reactive protein serum concentration (mg l− 1) | ≤0.5 ± 0 | 22 ± 13 | ≤0.0001 |
Procalcitonin serum concentration (ng ml− 1) | n/a | 56 ± 96 | |
SAPS II | n/a | 34 ± 10 | |
SOFA | n/a | 14 ± 2 | |
30-day survival (%) | 100 | 56 | |
Gram-positive sepsis N (%) | n/a | 6 (33) | |
Gram-negative sepsis N (%) | n/a | 5 (28) | |
Mixed bacterial sepsis N (%) | n/a | 3 (17) | |
Viral sepsis N (%) | n/a | 0 | |
Mycotic sepsis N (%) | n/a | 2 (11) | |
Sepsis without microbial detection N (%) | n/a | 2 (11) | |
Source of infection 1) Pneumonia, N | n/a | 8 | |
2) Acute respiratory distress syndrome (ARDS) subsequent to prior Pneumonia, but only microbial detection in blood, N | n/a | 4 | |
3) Urinary tract infection, N | n/a | 1 | |
4) Abdominal infection | n/a | 2 | |
5) Thoracic infection | n/a | 1 | |
6) No focus detected | n/a | 2 |