Variable versus fixed-rate infusion of phenylephrine during cesarean delivery: a randomized controlled trial

BMC Anesthesiology

Table 2 Maternal outcomes Data are presented as frequency (%), and median (quartiles), and mean (standard devition)

	Intermittent boluses group (n = 76)	Fixed infusion group (n = 70)	Variable infusion group (n = 71)	P1	P2	P3
Maternal hypotension	51(67%)	26(37%)^a	22(31%)^a	0.001	0.001	0.48
Severe maternal hypotension	12(16%)	10(14%)	12(17%)	0.82	1	0.82
Post-delivery hypotension	5(7%)	6(9%)	4(6%)	0.76	1	0.53
Bradycardia	6(7.9%)	12(17.2%)^a	17(23.9%)+a	0.15	0.03	0.44
Hypertension	0(0%)	4(6%)	8(11%)^a	0.05	0.002	0.34
Nausea	5(7%)	4(6%)	4(6%)	1	1	1
Vomiting	3(3.9%)	1(1.4%)	1(1.4%)	0.6	0.62	1
Hypotensive episodes	1(0,2)	0(0,1)^a	0(0,1) ^a	0.001	0.001	0.36
Mothers with 2nd hypotensive episode	25(33%)	9(13%)^a	6(9%)^a	0.008	0.008	0.62
PE consumption (mcg)	150(100,208)	1750(1400,2200)^a	1510(1200,2100)^{a, b}	0.001	0.001	0.014
No. of physician interventions per mother	1.42(1.44)	1.1(1.44)	1.89(1.86) ^b	0.081	0.21	0.008
Physician interventions
– Zero	24(32%)	34(49%)^a	22(31%)^b	0.043	0.96	0.04
– > 1	27(36%)	20(29%) 11(16%)	34(48%) ^b	0.38 1	0.14	0.03
– > 2	13(17%)		24(34%) ^ab		0.02	0.02

PE phenylephrine, ep. episodes, ^a denotes statistical significance compared to single bolus group, ^b denotes statistical significance compared to fixed infusion group. P1: P value between intermittent bolus group and fixed infusion group, P2: P value between intermittent bolus group and variable infusion group, P3: P value between fixed infusion group and variable infusion group

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