From: Thrombelastometry guided blood-component therapy after cardiac surgery: a randomized study
Variables | CONTROL | ROTEMĀ® | p-value |
---|---|---|---|
Baseline values | |||
āNumber, n (%) | 26 (47) | 29 (53) | Ā |
āAge [years] | 66.9āĀ±ā11.1 | 66.7āĀ±ā10.0 | 0.87 |
āMale sex, n (%) | 22 (85) | 26 (90) | 0.70 |
āBMI | 24.5 [23.0;29.0] | 27.0 [25.0;29.5] | 0.07 |
āLog. EuroSCORE [%] | 10.2āĀ±ā10.5 | 7.4āĀ±ā6.9 | 0.40 |
āSTS ā Score [%] | 3.7āĀ±ā3.9 | 3.3āĀ±ā3.1 | 0.73 |
āBiplane LVEF [%] | 60.0 [41.5;65.0] | 59.0 [50.0;65.0] | 1.00 |
āDiabetes mellitus, n (%) | 7 (27) | 7 (24) | 1.00 |
āCOPD, n (%) | 1 (4) | 5 (17) | 0.20 |
āCreatinine [mmol/l] | 98.0 [80.0;109.3] | 106.0 [86.5;130.5] | 0.07 |
āDeep hypothermic circulatory arrest, n (%) | 2 (8) | 1 (3) | 0.60 |
āRe-operation, n (%) | 2 (8) | 4 (14) | 0.67 |
Perioperative details | |||
āCPB time [min] | 161.4āĀ±ā59.8 | 159.3āĀ±ā41.3 | 0.93 |
āCross-clamp time [min] | 105.8āĀ±ā41.9 | 99.3āĀ±ā31.7 | 0.84 |
āHeparin [IU] | 31,528.0āĀ±ā9526.2 | 34,925.9āĀ±ā10,049.6 | 0.16 |
āProtamin [IU] | 30,720.0āĀ±ā7924.2 | 31,000.0āĀ±ā5699.1 | 0.46 |
RBCs [units] | 1.4āĀ±ā2.0 | 1.2āĀ±ā2.1 | 0.45 |
FFPs [units] | 1.2āĀ±ā1.9 | 0.7āĀ±ā1.2 | 0.52 |
Platelet concentrates [units] | 0.3āĀ±ā0.7 | 0.1āĀ±ā0.4 | 0.20 |
Fibrinogen [g] | 0.2āĀ±ā0.7 | 0.1āĀ±ā0.5 | 1.00 |
PPSB [IU] | 200.0āĀ±ā707.1 | 166.7āĀ±ā500.0 | 1.00 |
AT3, IU, meanāĀ±āSD | 200.0āĀ±ā707.1 | 129.6āĀ±ā429.5 | 1.00 |
Aprotinin [Mio IU] | 0.6āĀ±ā0.9 | 1.9āĀ±ā9.6 | 0.03 |
Tranexamic acid [g] | 1.6āĀ±ā1.5 | 1.8āĀ±ā1.5 | 1.00 |
ACT (prior to ICU transfer) [sec] | 134.1āĀ±ā16.1 | 130.7āĀ±ā20.2 | 0.18 |
Hct (prior to ICU transfer) [%] | 28.1āĀ±ā4.4 | 28.4āĀ±ā3.8 | 0.71 |
Temperature (prior to ICU transfer) [Ā°C] | 36.4 [36.0;36.6] | 36.3 [36.0;36.6] | 0.70 |
Postoperative - ICU | |||
āRBCs [units] | 7.1ā+ā10.8 | 3.8ā+ā3.8 | 0.28 |
āFFPs [units] | 4.2āĀ±ā5.6 | 1.7āĀ±ā2.8 | 0.07 |
āPlatelet concentrates [units] | 1.1āĀ±ā1.3 | 0.4āĀ±ā0.6 | 0.02 |
āFibrinogen [g] | 0.2āĀ±ā0.6 | 0.9āĀ±ā1.2 | 0.01 |
āPPSB [IU] | 0.0āĀ±ā0.0 | 0.0āĀ±ā0.0 | 1.00 |
āAT3 [IU] | 40.0āĀ±ā200.0 | 0.0āĀ±ā0.0 | 0.48 |
āAprotinin [Mio IU] | 0.4āĀ±ā0.8 | 0.0āĀ±ā0.0 | 0.02 |
āTranexamic acid [g] | 0.1āĀ±ā0.4 | 0.1āĀ±ā0.4 | 1.00 |
Blood loss within first 24āh [ml] | 2056.8āĀ±ā974.5 | 1538.2āĀ±ā806.4 | 0.03 |
Re-thoracotomy, n (%) | 7 (27) | 6 (21) | 0.75 |
30-day mortality, n (%) | 3 (12) | 0 (0) | 0.10 |
5-year mortality, n (%) | 4 (15) | 0 (0) | 0.03 |