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Table 5 Clinical characteristics of 55 patients with ā€œlongā€ CPB time (ā‰„ 115ā€‰min)

From: Thrombelastometry guided blood-component therapy after cardiac surgery: a randomized study

Variables

CONTROL

ROTEMĀ®

p-value

Baseline values

ā€ƒNumber, n (%)

26 (47)

29 (53)

Ā 

ā€ƒAge [years]

66.9ā€‰Ā±ā€‰11.1

66.7ā€‰Ā±ā€‰10.0

0.87

ā€ƒMale sex, n (%)

22 (85)

26 (90)

0.70

ā€ƒBMI

24.5 [23.0;29.0]

27.0 [25.0;29.5]

0.07

ā€ƒLog. EuroSCORE [%]

10.2ā€‰Ā±ā€‰10.5

7.4ā€‰Ā±ā€‰6.9

0.40

ā€ƒSTS ā€“ Score [%]

3.7ā€‰Ā±ā€‰3.9

3.3ā€‰Ā±ā€‰3.1

0.73

ā€ƒBiplane LVEF [%]

60.0 [41.5;65.0]

59.0 [50.0;65.0]

1.00

ā€ƒDiabetes mellitus, n (%)

7 (27)

7 (24)

1.00

ā€ƒCOPD, n (%)

1 (4)

5 (17)

0.20

ā€ƒCreatinine [mmol/l]

98.0 [80.0;109.3]

106.0 [86.5;130.5]

0.07

ā€ƒDeep hypothermic circulatory arrest, n (%)

2 (8)

1 (3)

0.60

ā€ƒRe-operation, n (%)

2 (8)

4 (14)

0.67

Perioperative details

ā€ƒCPB time [min]

161.4ā€‰Ā±ā€‰59.8

159.3ā€‰Ā±ā€‰41.3

0.93

ā€ƒCross-clamp time [min]

105.8ā€‰Ā±ā€‰41.9

99.3ā€‰Ā±ā€‰31.7

0.84

ā€ƒHeparin [IU]

31,528.0ā€‰Ā±ā€‰9526.2

34,925.9ā€‰Ā±ā€‰10,049.6

0.16

ā€ƒProtamin [IU]

30,720.0ā€‰Ā±ā€‰7924.2

31,000.0ā€‰Ā±ā€‰5699.1

0.46

RBCs [units]

1.4ā€‰Ā±ā€‰2.0

1.2ā€‰Ā±ā€‰2.1

0.45

FFPs [units]

1.2ā€‰Ā±ā€‰1.9

0.7ā€‰Ā±ā€‰1.2

0.52

Platelet concentrates [units]

0.3ā€‰Ā±ā€‰0.7

0.1ā€‰Ā±ā€‰0.4

0.20

Fibrinogen [g]

0.2ā€‰Ā±ā€‰0.7

0.1ā€‰Ā±ā€‰0.5

1.00

PPSB [IU]

200.0ā€‰Ā±ā€‰707.1

166.7ā€‰Ā±ā€‰500.0

1.00

AT3, IU, meanā€‰Ā±ā€‰SD

200.0ā€‰Ā±ā€‰707.1

129.6ā€‰Ā±ā€‰429.5

1.00

Aprotinin [Mio IU]

0.6ā€‰Ā±ā€‰0.9

1.9ā€‰Ā±ā€‰9.6

0.03

Tranexamic acid [g]

1.6ā€‰Ā±ā€‰1.5

1.8ā€‰Ā±ā€‰1.5

1.00

ACT (prior to ICU transfer) [sec]

134.1ā€‰Ā±ā€‰16.1

130.7ā€‰Ā±ā€‰20.2

0.18

Hct (prior to ICU transfer) [%]

28.1ā€‰Ā±ā€‰4.4

28.4ā€‰Ā±ā€‰3.8

0.71

Temperature (prior to ICU transfer) [Ā°C]

36.4 [36.0;36.6]

36.3 [36.0;36.6]

0.70

Postoperative - ICU

ā€ƒRBCs [units]

7.1ā€‰+ā€‰10.8

3.8ā€‰+ā€‰3.8

0.28

ā€ƒFFPs [units]

4.2ā€‰Ā±ā€‰5.6

1.7ā€‰Ā±ā€‰2.8

0.07

ā€ƒPlatelet concentrates [units]

1.1ā€‰Ā±ā€‰1.3

0.4ā€‰Ā±ā€‰0.6

0.02

ā€ƒFibrinogen [g]

0.2ā€‰Ā±ā€‰0.6

0.9ā€‰Ā±ā€‰1.2

0.01

ā€ƒPPSB [IU]

0.0ā€‰Ā±ā€‰0.0

0.0ā€‰Ā±ā€‰0.0

1.00

ā€ƒAT3 [IU]

40.0ā€‰Ā±ā€‰200.0

0.0ā€‰Ā±ā€‰0.0

0.48

ā€ƒAprotinin [Mio IU]

0.4ā€‰Ā±ā€‰0.8

0.0ā€‰Ā±ā€‰0.0

0.02

ā€ƒTranexamic acid [g]

0.1ā€‰Ā±ā€‰0.4

0.1ā€‰Ā±ā€‰0.4

1.00

Blood loss within first 24ā€‰h [ml]

2056.8ā€‰Ā±ā€‰974.5

1538.2ā€‰Ā±ā€‰806.4

0.03

Re-thoracotomy, n (%)

7 (27)

6 (21)

0.75

30-day mortality, n (%)

3 (12)

0 (0)

0.10

5-year mortality, n (%)

4 (15)

0 (0)

0.03

  1. Data presented as numbers (%), meanā€‰Ā±ā€‰SD or as median (interquartile range)