Table 4 Clinical data of both randomized groups
From: Thrombelastometry guided blood-component therapy after cardiac surgery: a randomized study
Variables | CONTROL | ROTEM® | p-value |
|---|---|---|---|
Perioperative details | |||
Number, n (%) | 52 (50) | 52 (50) | |
CPB time [min.] | 109.2 ± 74.6 | 119.8 ± 60.6 | 0.44 |
Cross-clamp time [min] | 71.5 ± 51.0 | 77.3 ± 39.5 | 0.33 |
Heparine dosage [IU] | 28,249.0 ± 10,419.0 | 33,364.6 ± 12,000.3 | 0.01 |
Protamine dosage [IU] | 28,580.0 ± 9165.4 | 28,851.1 ± 8257.4 | 0.47 |
RBCs [units] | 1.1 ± 1.7 | 1.0 ± 1.9 | 0.48 |
FFPs [units] | 0.9 ± 1.7 | 0.5 ± 1.1 | 0.38 |
Platelet concentrates [units] | 0.1 ± 0.5 | 0.2 ± 0.5 | 0.97 |
Fibrinogen [g] | 0.1 ± 0.6 | 0.1 ± 0.4 | 0.71 |
PPSB [IU] | 137.3 ± 566.4 | 135.4 ± 422.0 | 0.50 |
AT3 [IU] | 137.3 ± 566.4 | 83.3 ± 331.6 | 0.72 |
Aprotinin, [Mio IU] | 0.3 ± 0.7 | 1.1 ± 7.2 | 0.09 |
Tranexamic acid [g] | 1.6 ± 1.5 | 1.9 ± 1.5 | 0.22 |
ACT (prior to ICU transfer) [sec] | 135.4 ± 16.5 | 132.3 ± 20.3 | 0.09 |
Hct (prior to ICU transfer) [%] | 28.9 ± 3.9 | 28.6 ± 4.1 | 0.70 |
Temperature (prior to ICU transfer) [°C] | 36.3 [36.0;36.6] | 36.4 [35.9;36.6] | 0.78 |
Postoperative - ICU | |||
RBCs [units] | 5.2 + 8.1 | 4.4 + 3.7 | 0.73 |
FFPs [units] | 3.2 ± 4.7 | 2.2 ± 4.1 | 0.17 |
Platelet concentrates [units] | 0.7 ± 1.1 | 0.4 ± 0.8 | 0.16 |
Fibrinogen [g] | 0.2 ± 0.6 | 0.8 ± 1.1 | 0.01 |
PPSB [IU] | 58.8 ± 420.1 | 81.6 ± 399.8 | 0.61 |
AT3 [IU] | 19.6 ± 140.0 | 20.4 ± 142.9 | 1.00 |
Aprotinin [Mio IU] | 0.5 ± 0.9 | 0.1 ± 0.4 | 0.01 |
Tranexamic acid [g] | 0.1 ± 0.4 | 0.0 ± 0.3 | 1.00 |
Blood loss within first 24 h [ml] | 1867.4 ± 827.4 | 1599.1 ± 834.3 | 0.07 |
Re-thoracotomy, n (%) | 15 (29) | 13 (25) | 0.83 |
30-day mortality, n (%) | 4 (8) | 1 (2) | 0.17 |
5-year mortality, n (%) | 6 (12) | 2 (4) | 0.14 |