Table 2 Transfusion protocol for the control group

1.

Standard coagulation tests: platelets count, Fibrinogen, AT3, PTT, INR/Quick, α2-Antiplasmin, ACT

2.

ACT > 160 s = > 5000 IE Protamin (once)

3.

PTT > 60 s = > FFP units (kg body weight)^a or if Quick < 50%

4.

Platelets count <100,103/μl = > 1 platelet concentrate

5.

Fibrinogen <1,2 g/l = > 2 g Fibrinogen

6.

α2-Antiplasmin <80% = > 2 Mio IE Aprotinin / 2 g Tranexamic acid

• In case of persistent bleeding - > re-testing according to (1) and further therapy as suggested by the protocol.

• 2000 IE PPSB if INR > 2.0 and known liver dysfunction or previous Coumadin therapy.

• 2000 IE AT3 if an increase > 50% (prothrombin time) is not to be expected via FFP-substitution.