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Table 3 Haemostasis at the beginning and the end of liver transplantation as judged by conventional laboratory examinations and ROTEM™

From: Safety of coagulation factor concentrates guided by ROTEM™-analyses in liver transplantation: results from 372 procedures

 

Initial values

Final values

 

Median

Percentiles

Median

Percentiles

Significance niveau

 

25%

75%

 

25%

75%

EXTEM

 CT (s)

55

46

78

62

51

83

p < 0.001

 CFT (s)

119

82

177.5

163

117.5

251

p < 0.001

 MCF (mm)

53

45

62

49

43

57

p < 0.001

 Alpha (°)

68

59

75

64

54

72

p < 0.001

INTEM

 CT (s)

188.5

162

217.8

254.5

205

326.8

p < 0.001

 CFT (s)

104

67

156

153.5

100

240.3

p < 0.001

 MCF (mm)

52

45

61

49

42

56

p < 0.001

 Alpha (°)

70

61

77

65

55

72

p < 0.001

FIBTEM

 CT (s)

54

45

75.5

61.5

50

83

p = 0.02

 CFT (s)

*

*

*

*

*

*

 

 MCF (mm)

15

11

23

11

8

15

p < 0.001

 alpha (°)

67

54.5

74

63

51

73

p < 0.001

APTEM

 CT (s)

64

51

88.5

71

55

93

p < 0.001

 CFT (s)

128

92

182

167

119.5

247.5

p < 0.001

 MCF (mm)

52

45.8

61

49

43

55

p < 0.001

 alpha (°)

67

59

73

63

54

71

p < 0.001

 INR

1.48

1.26

1.81

2.47

1.85

3.26

p < 0.001

 aPTT (s)

45

36.9

56

81

58.1

108.9

p < 0.001

 fibrinogen (mg/dl)

175.3

114.8

257

118

91

162

p < 0.001

 antithrombin (%)

45.6

32

68.4

24.5

12.5

37.9

p < 0.001

 platelets (1/103 μl)

92

62

148.5

98

71

139

n.s.

 Hb (g/dl)

10.1

8.9

11.5

9.9

9

11.1

p < 0.001

  1. ROTEM™ values shown are clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), and angle alpha (alpha). Whole blood samples were activated with tissue factor (EXTEM™), elagic acid (INTEM™), tissue factor and platelet inhibition (FIBTEM™), and tissue factor and fibrinolysis inhibition (APTEM™). Conventional laboratory variables are international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen concentration, antithrombin activity, platelet count, and hemoglobin concentration (Hb). ROTEM™ guided haemostasis management resulted in a slight decrease in most haemostatic variables during the transplantation procedure. Note, that CFT values are not generated in the FIBTEM assay. Differences between initial and final values were determined using the paired Wilcoxon test.
  2. *: no clot formation detectable
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BMC Anesthesiology

ISSN: 1471-2253

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