Combined ultrasound and nerve stimulator-guided deep nerve block may decrease the rate of local anesthetics systemic toxicity: a randomized clinical trial

Table 3 Summary of Events of Local Anesthetic Systemic Toxicity (LAST)

Group	Sex	Age(Y)	Weight(kg)	Height(cm)	Signs and Symptoms	Occurrence time	Treatment	Duration time (min)
N	F	35	52.5	155	Lips numbness, Left hand twitch	17	M2	6
N	F	46	55	155	Lips numbness	11	/	5
N	F	65	62.5	163	Agitation, Chest tightness	9	/	3
N	F	19	35.5	149	Tachycardia, Seizures	12/22	M2 P200V	80^a
U	F	46	54	158	Tongue numbness, Tinnitus	8	M2	9
U	F	53	54	160	Tongue numbness, Left hand and leg twitch	13/17	M2	8
U	F	26	70	161	Tongue numbness	18	/	4
U	F	41	50	156	Unconsciousness, Tachycardia, Hypertension	8	M2 P200	63^a
U	F	61	60	155	Agitation	9	/	3
U	F	46	60	159	Scream, Unconsciousness	1	M2 P200	100^a
U	F	32	51	160	Tachycardia	7	M2 D0.5	25
U	M	81	63	152	Right hand twitch, Unconsciousness	4/9	M2	15
U	F	62	58	150	Transient numbness of right hand and leg	20	/	4
U	F	26	46	161	Twitch	12	M2	5
U	F	47	60	145	Hypertension, Tachycardia, Agitation	10	M2	25
U	F	37	48	153	anxiety, Confusion	11	M2	15
M	F	35	64	163	Tinnitus, Whole body numbness	8	M2	10
M	M	21	60	170	Tongue numbness	11	/	6

Treatment: M2 means venous injection of Midazolam 2 mg; P200 means continuous intravenous infusion of Propofol 200 mg with the rate of 3 mg^.kg^-1.h⁻¹; D0.5 means continuous intravenous infusion of Dexmedetomidine with the rate of 0.5 μg^.kg^-1.h⁻¹; V means mechanical ventilation. Dosage of local anesthtic: 0.4%Ropivacaine+ 0.4% Lidocaine, 3 mg/kg);
^aThe main reason of long duration time was the use of propofol

ISSN: 1471-2253