Perioperative opioid requirements of patients receiving sublingual buprenorphine-naloxone: a case series

BMC Anesthesiology

Table 3 Opioids administered for operations and during first 24hours postoperation to patients stratified by type of anesthesia and buprenorphine-naloxone (SL-BUP) use before surgery^a,b,c

Time of Opioid Administration	General Anesthesia Only		P Value^d	Combined General Anesthesia With Regional Block		P Value^d
Time of Opioid Administration	SL-BUP Discontinued (n = 7)	SL-BUP Continued (n = 10)	P Value^d	SL-BUP Discontinued (n = 5)	SL-BUP Continued (n = 7)	P Value^d
Intraoperative	60 [33–179]	32 [18–61]	.06	25 [20–40]	15 [5–39]	.33
PACU only	15 [6–24]	13 [5–26]	.98	15 [8–15]	13 [5–20]	.96
24 h after PACU discharge	111 [32–233]	56 [38–105]	.33	105 [33–110]	60 [38–134]	.86
Total 24-h	199 [110–411]^e	106 [58–160]^f	.15	140 [100–157]^e	100 [73–203]^f	.94

Abbreviations: PACU post-anesthesia care unit; SL-BUP sublingual formulation of buprenorphine and naloxone (Suboxone)
^aData are shown as milligrams of intravenous morphine equivalents; ^b Values are shown as median [interquartile range]; ^c Of 32 patients, 3 do not have recovery room data because of direct admission to the intensive care unit; ^d2-sample t test after log transformation; ^eComparison of these data yielded P = .37; ^fComparison of these data yielded P = .90

ISSN: 1471-2253