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Table 4 Impact of SF on antimicrobial therapy

From: Multiplex polymerase chain reaction to diagnose bloodstream infections in patients after cardiothoracic surgery

No.

Age range, gender

POD, Surgery

Identified pathogen in SF

Identified pathogen in BC

Initial antimicrobial therapy

Adjustment of therapy

Outcome after adjustment of therapy

1

50–59, 1

53, CABG, AVR, MVS

Aspergillus fumigatus

Meropenem, Vancomycin

Escalation with voriconazole

survived

2

50–59, 1

38, LTX

Aspergillus fumigatus

Meropenem, Vancomycin, Fluconazole

Escalation with voriconazole, discontinuation of fluconazole

died

3

70–79, 2

CABG, AVR, MVS, TVS

Aspergillus fumigatus

Piperacilline/Tazobactam

Escalation with voriconazole

died

4

50–59, 1

18, Aortic surgery

Candida albicans

Candida albicans

Ciprofloxacine, Vancomycin, Colistin

Escalation with caspofungin

died

5

60–69, 2

33, AVR, MVS

Candida albicans

Meropenem, Vancomycin

Escalation with fluconazole

survived

6

60–69, 1

47, AVR

Candida albicans

Linezolid, Imipenem

Escalation with caspofungin

survived

7

70–79, 1

21. CABG, MVS, TVS

Enterococcus faecium

CoNS

Piperacilline/Tazobactam

Escalation with vancomycin

died

8

20–29, 1

49. LTX

Pseudomonas aeruginosa

Vancomycin, Ceftazidime

Escalation with colistin

survived

  1. AVR Aortic valve replacement, BC blood culture, CABG coronary artery bypass grafting, CoNS Coagulase-negative staphylococci, LTX lung transplant, MVS mitral valve surgery, POD postoperative day, SF SeptiFast, TVS tricuspid valve surgery. To ensure patient’s anonymity, gender was discriminated in 1 and 2