Table 2 Pharmacokinetic (PK) model parameter estimates and stability of the parameters using bootstrap validation (BS)
Parameter | PK Model | BS PK Model |
|---|---|---|
Mean (CV%) | Mean (CV%) | |
Fixed effects | ||
 CL (l/min) | 1.37 (7.0) | 1.38 (5.1) |
 Q (l/min) | 1.15 (29.4) | 1.16 (44.1) |
 V1 (l) | 3.6 (10.2) | 3.45 (11.3) |
 V2 (l) | 76.8 (5.0) | 77.3 (5.0) |
Interindividual variability | ||
 ω2 of CL in % | 22.1 (28.7) | 21.4 (25.7) |
 Residual error | ||
 σ2 | 19.0% (11.9) | 18.4% (12.5) |
Performance measures | ||
 (−2LL) | − 452 | − 464.7 |