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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

Fig. 1

Schematic representation of the pharmacokinetic (PK) -pharmacodynamic (PD) model for propofol with V1, V2, Q and Cl representing the two compartment pharmacokinetic model and a central and peripheral effect-site compartment characterizing the pharmacodynamics. Ke0 is the first-order rate constant from central pharmacokinetic compartment to central effect site compartment which equals the rate constant for drug loss of the effect-site compartment, ke12 and ke21 represent the rate constants from central to peripheral effect site compartment and back. The propofol concentration in the central effect site-compartment is directly responsible for the measured Bispectral Index (BIS) or composite A-Line ARX Index (cAAI) as described using eq. 4

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BMC Anesthesiology

ISSN: 1471-2253

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