Fig. 4

HPX treatment contributed to the repair of the BBB impaired by focal cerebral I/R injury. When compared with the sham operation, the focal cerebral I/R injury resulted in an increase in the extravasation of EB (a), brain water content (b), along with a decrease in VE-cadherin expression (d) and the ratio of the mRNA level of Ang1 and Ang2 (c) in rats of the MCAO group. HPX treatment facilitated the repair of the BBB as shown by a reduction in the extravasation of EB (a), brain water content (b), and the prevention of the decrease in VE-cadherin expression (d) and the mRNA ratio of Ang1 to Ang2 (d). When ZnPPIX was given along with HPX to rats after I/R injury, the positive effect of HPX on repairing the BBB integrity was blocked (a, b, c and d). ^*P < 0.05 vs. sham group; ^#P < 0.05 vs. vehicle group; ^※P < 0.05 vs. HPX group