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Table 3 Changes in sublingual microcirculation and NIRS-derived parameters from baseline to end-surgery in the two groups of patients receiving balanced anaesthesia or total intravenous anaesthesia

From: Changes in the sublingual microcirculation following aortic surgery under balanced or total intravenous anaesthesia: a prospective observational study

 

Balanced anaesthesia

TIVA

p for interaction (2-way ANOVA)

Baseline

end-surgery

baseline

end-surgery

MFI (small vessels) [AU]

2.67 [2.50–2.75]

2.83 [2.37–2.98]

2.75 [2.58–2.90]

2.67 [2.42–2.81]

Abnormal MFIa (n, %)

9, 45%

6, 30%

7, 35%

9, 45%

FHI [AU]

0.15 [0.00–0.29]

0.18 [0.02–0.36]

0.23 [0.09–0.28]

0.19 [0.10–0.38]

TVD (small) (mm/mm2)

18.4 ± 3.8

21.0 ± 4.7*

19.8 ± 4.0

20.7 ± 4.5

0.216

TVD (medium) (mm/mm2)

1.5 [0.9–2.2]

1.2 [1.1–1.5]

0.8 [0.6–1.1]##

0.5 [0.1–0.8]###

PVD (small) (mm/mm2)

16.6 ± 4.2

19.1 ± 5.4*

18.1 ± 4.2

19.2 ± 4.9

0.302

PVD (medium) (mm/mm2)

1.5 [0.9–2.2]

1.2 [1.1–1.5]

0.8 [0.6–1.1]##

0.5 [0.1–0.8]###

PPV (small, %)

91 [83–97]

91 [82–97]

96 [83–98]

95 [90–97]

StO2 (%)

83 ± 5

86 ± 7

82 ± 6

85 ± 9

0.975

StO2 Downslope 1 (%/min)

−8.0 [−10.8, −6.8]

−7.8 [− 10.4, − 6.9]

− 8.8 [− 12.0, − 7.8]

−8.1 [− 11.1, − 5.9]**

StO2 Downslope 2 (%/min)

−8.2 ± 3.3

− 8.0 ± 4.8

−8.2 ± 2.8

− 8.0 ± 3.4

0.962

Delta Downslope (2–1) (%/min)

1.1 [− 0.5, 2.4]

−0.1 [− 1.6, 1.8]

0.9 [− 0.8, 3.9]

−0.7 [− 1.4, 1.0]

StO2 Upslope (%/min)

226 ± 64

206 ± 103

264 ± 84

247 ± 77

0.900

AUC StO2 (%*min)

14.8 ± 8.1

25.6 ± 14.8*

20.4 ± 6.0

26.1 ± 19.1

0.359

THI [AU]

15.2 ± 2.0

15.3 ± 3.1

14.6 ± 3.3

12.8 ± 3.6#

0.140

  1. *p < 0.05 **p < 0.01 versus baseline, #p < 0.05 ##p < 0.01 ###p < 0.001 versus time-matched balanced anesthesia. Two-way Analysis of Variance (ANOVA) with Sidack’s multiple comparisons test or Wilcoxon and Mann-Whitney U test, as appropriate. Data are expressed as mean ± standard deviation or median [1st-3rd quartile], as appropriate
  2. aAn abnormal MFI was defined as an MFI lower than 2.6 [25]
  3. NIRS near infrared spectroscopy, TIVA total intravenous anaesthesia, MFI microvascular flow index, AU arbitrary unit, FHI flow heterogeneity index, TVD total vessel density, PVD perfused vessel density, PPV percentage of perfused vessels, StO2 tissue oxygen saturation, AUC StO2 area under the curve of StO2, THI tissue haemoglobin index