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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368

Fig. 1

Sevoflurane, as an additive to HTK solution, prevented gap junction Remodelling and electrophysiological properties promoting arrhythmogenesis, and also resulted in Cx43 phosphorylation at Ser368. a Quantitative analysis of the Western blotting results for Cx43 and Cx43-pS386 levels. b Western blot analysis of total Cx43 and Cx43-pS386 levels. c Ratio of total Cx43 to Cx43-pS386. d Cx43 distribution via immunohistochemical methods (400 ×). The black arrow indicates the brownish- red granular material as the Cx43 protein. The two upper images, show heterogeneous distribution and lateralization of Cx43 in the Control group. The two lower images show homogeneous distribution and stabilization of Cx43 in the Sevo-HTK group. e Difference in the RA between the groups. f Difference in the conduction velocities. g Similar TDR in the two groups

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BMC Anesthesiology

ISSN: 1471-2253

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